Avaliação descritiva das dispensações concomitantes de antidepressivos na Secretaria Municipal de Saúde do município de Belo Horizonte

Abstract

Depression is characterized by feelings of sadness and guilt, as well as physiological changes related to weight and sleep alterations. Brazilians have the highest levels of depression in Latin America, which will impact not only the quality of life but also have public health costs. Data from the DATASUS system have been shown that depression accounts for 23% of outpatient and hospital care in the SUS. Antidepressants drugs are used to treat acute, moderate and severe manifestations of depression. They are safe and effective for the majority of the population, however prescribing caution is suggested, since these drugs may induce important side effects, as well as are potential risks for drug interactions. There are few reports focusing in the use of antidepressants in the Brazilian population. For this reason, studies employing incidence and prescription of antidepressants became relevant. The main purpose of this study was verify the prevalence of antidepressant associations prescribed at the pharmacies of the municipal health department of the city of Belo Horizonte. We also verified the potential drug interactions of the concomitant prescriptions and the prevalence of overdose. Moreover, we classified the interactions observed according their intensity. For this, we assessed the database of prescriptions from January to June 2017. The data were extracted from the Network Health Management System (SISREDE), consolidated and analyzed using IBM SPSS Statistics 20.0 softwares; the drug interactions were classified according to the Drug Interaction Checker database of Medscape according to their intensity in levels: low grade or non-significant, moderate or significant and high grade or very significant. The results showed that in 95.8% of the dispensations did not occur overdosage, but a significant prevalence of overdosage was observed in elderly patients, representing 70.46%, being most of them tricyclic antidepressants. There was a prevalence of 9.5% of the association of antidepressants. In these associations we observed that 8.30% are relevant because they were prescribed for patients 60 years or older. We also observed that 90.3% of the associations were of the SSRI + ADT type. From our data, we conclude that is important to alert the prescribers to the risks of association and overdose for patients specially in elderly people