Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/42073
Type: Artigo de Periódico
Title: Biocompatibility assessment of fibrous nanomaterials in mammalian embryos
Authors: Michele Munk Pereira
Humberto de Mello Brandão
Luiz Sérgio de Almeida Camargo
Carolina Capobiango Romano Quintão
Saulo R. Silva
Eliza Diniz de Souza
Nádia Rezende Barbosa Raposo
José Manoel Marconcini
Ado Jorio de Vasconcelos
Luiz Orlando Ladeira
Abstract: Currently there is a growing interest in the use of nanotechnology in reproductive medicine and reproductive biology. However, their toxic effects on mammalian embryos remain poorly understood. In this work, we evaluate the biocompatibility of two fibrous nanomaterials (NMs): cotton cellulose nanofibers (CNF) and carboxylated multiwalled carbon nanotubes (MWCNT-COOH), by performing an investigation of the embryonic development, gene expression (biomarkers focused on cell stress, apoptosis and totipotency) and in situ apoptosis in bovine embryos. Exposure to NMs did not interfere in preimplantation development or in the incidence of apoptosis in the bovine embryo, but they did affect the gene expression. The results presented are important for an understanding of the toxicity of cotton CNF and MWCNT-COOH on mammalian embryos. To our knowledge, we report the first evaluation of biocompatibility between these NMs on preimplantation embryos, which may open a new window for reproductive biomedical applications.
Subject: Nanomateriais
Biocompatibilidade
Apoptose
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: ICX - DEPARTAMENTO DE FÍSICA
Rights: Acesso Restrito
metadata.dc.identifier.doi: 10.1016/j.nano.2016.01.006
URI: http://hdl.handle.net/1843/42073
Issue Date: 2016
metadata.dc.url.externa: https://www.sciencedirect.com/science/article/pii/S1549963416000769?via%3Dihub
metadata.dc.relation.ispartof: Nanomedicine: Nanotechnology, Biology and Medicine
Appears in Collections:Artigo de Periódico

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