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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44255
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dc.creatorKarla Nayara de Oliveira Santanapt_BR
dc.creatorDeborah Farias Lelispt_BR
dc.creatorKeila Lopes Mendespt_BR
dc.creatorJamille Fernandes Lulapt_BR
dc.creatorAlanna Fernandes Paraísopt_BR
dc.creatorJoão Marcus Oliveira Andradept_BR
dc.creatorJohn David Feltenbergerpt_BR
dc.creatorJúnio Cota Silvapt_BR
dc.creatorDiego Vicente da Costapt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.date.accessioned2022-08-15T12:45:09Z-
dc.date.available2022-08-15T12:45:09Z-
dc.date.issued2016-11-01-
dc.citation.volume51pt_BR
dc.citation.issue12pt_BR
dc.citation.spage1375pt_BR
dc.citation.epage1384pt_BR
dc.identifier.doi10.1007/s11745-016-4209-ypt_BR
dc.identifier.issn1558-9307pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44255-
dc.description.resumoLipogenesis is the process by which fatty acids are synthesized. In metabolic syndrome, an insulin resistant state along with high plasma levels of free fatty acids (FFA) and hyperglycemia may contribute to the lipogenic process. The aim of the present study was to investigate the effects of oral administration of metformin on the expression of lipogenic genes and glycemic profile in mice fed with low-carbohydrate high-fat diet by evaluating their metabolic profile. SWISS male mice were divided into 4 groups (N = 7) that were fed with standard (ST), standard plus metformin (ST + MET), low-carbohydrate high-fat diet (LCHFD) and low-carbohydrate high-fat diet plus metformin (LCHFD + MET) (100 mg kg−1 diet) diets respectively. Food intake, body weight and blood parameters, such as glucose tolerance, insulin sensitivity, glucose, HDL-c, total cholesterol, triglycerides, ASL and ALT levels were assessed. Histological analyses were performed on hematoxylin and eosin-stained epididymal adipose tissue histological specimens. The expression levels of peroxisome proliferator-activated receptor (PPARγ), sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), were assessed by RT-PCR. This study showed that metformin decreased adipocyte area, body weight and food consumption in obese animals when compared to the standard group. Furthermore, the expression of lipogenic markers in adipose tissue were diminished in obese animals treated with metformin. This data showed that oral administration of metformin improved glucose and lipid metabolic parameters in white adipose tissue by reducing the expression of lipogenesis markers, suggesting an important clinical application of MET in treating obesity-related diseases in metabolic syndrome.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofLipidspt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherSíndrome metabólicapt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherTecido adiposopt_BR
dc.subject.otherÁcidos graxos na nutrição humanapt_BR
dc.subject.otherHiperglicemiapt_BR
dc.titleMetformin reduces lipogenesis markers in obese mice fed a low-carbohydrate and high-fat dietpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s11745-016-4209-ypt_BR
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