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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/44355
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Campo DCValorIdioma
dc.creatorPatrícia Luciana Batista Domingospt_BR
dc.creatorMarcela Gonçalves Souzapt_BR
dc.creatorTalita Antunes Guimarãespt_BR
dc.creatorEliane Sobrinho Santospt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorCarlos Alberto de Carvalho Fragapt_BR
dc.creatorKimberly Marie Jonespt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.date.accessioned2022-08-18T13:17:37Z-
dc.date.available2022-08-18T13:17:37Z-
dc.date.issued2017-05-
dc.citation.volume213pt_BR
dc.citation.issue5pt_BR
dc.citation.spage496pt_BR
dc.citation.epage501pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.prp.2017.02.003pt_BR
dc.identifier.issn0344-0338pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44355-
dc.description.resumoObjective: the purpose of the current study is to investigate the association between E-cadherin methylation status, hypoxia and OSCC. Methods: HaCat and SCC9 cell lines were submitted to hypoxic treatment, followed by methylation profile analysis (MS-PCR) and analysis of the expression of mRNA gene E-cadherin (RT-PCR). Study group samples comprise individuals affected by potentially malignant lesions Potential Malignant Oral Lesion (PMOL, n = 18) and oral squamous cell carcinoma (OSCC, n = 28). The control group oral mucosa (OM, n = 15) of patients with an oral mucocele. Cell migration ability was evaluated a scratch wound assay in SCC9 and HaCat cell lines. Results: E-cadherin mRNA expression in the cell lines SCC9 and HaCat was significantly reduced under hypoxia, regardless of the methylation profile, when compared to the control group. No differences in methylation profile of the E-cadherin were observed among the groups OM, PMOL and OSCC. HaCat and SCC9 presented increases in cell migration rates under hypoxia. Conclusion: the current study demonstrates that hypoxia reduces E-cadherin expression and increase cell migration, regardless of the methylation profile. Additionally, no differences in E-cadherin methylation patterns were observed among OM, PMOL and OSCC.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPathology: Research and Practicept_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherBoca - Câncerpt_BR
dc.subject.otherGlicoproteínaspt_BR
dc.subject.otherMigração celularpt_BR
dc.subject.otherTumorespt_BR
dc.subject.otherCultura de célulaspt_BR
dc.titleHypoxia reduces the E-cadherin expression and increases OSCC cell migration regardless of the E-cadherin methylation profilept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0344033816303004pt_BR
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