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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44484
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dc.creatorEliane Macedo Sobrinho Santospt_BR
dc.creatorRogério Gonçalves da Rochapt_BR
dc.creatorHércules Otacílio Santospt_BR
dc.creatorTalita Antunes Guimarãespt_BR
dc.creatorCarlos Alberto de Carvalho Fragapt_BR
dc.creatorLuiz Henrique da Silveirapt_BR
dc.creatorPaulo Ricardo Batistapt_BR
dc.creatorPaulo Sérgio Lopes de Oliveirapt_BR
dc.creatorGeraldo Aclécio Melopt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.date.accessioned2022-08-23T13:35:05Z-
dc.date.available2022-08-23T13:35:05Z-
dc.date.issued2018-01-
dc.citation.volume214pt_BR
dc.citation.issue1pt_BR
dc.citation.spage30pt_BR
dc.citation.epage37pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.prp.2017.11.022pt_BR
dc.identifier.issn0344-0338pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44484-
dc.description.resumoGallic acid is a polyphenolic compost appointed to interfere with neoplastic cells behavior. Evidence suggests an important role of leptin in carcinogenesis pathways, inducing a proliferative phenotype. We investigated the potential of gallic acid to modulate leptin-induced cell proliferation and migration of oral squamous cell carcinoma cell lines. The gallic acid effect on leptin secretion by oral squamous cell carcinoma cells, as well as the underlying molecular mechanisms, was also assessed. For this, we performed proliferation, migration, immunocytochemical and qPCR assays. The expression levels of cell migration-related genes (MMP2, MMP9, Col1A1, and E-cadherin), angiogenesis (HIF-1α, mir210), leptin signaling (LepR, p44/42 MAPK), apoptosis (casp-3), and secreted leptin levels by oral squamous cell carcinoma cells were also measured. Gallic acid decreased proliferation and migration of leptin-treated oral squamous cell carcinoma cells, and reduced mRNA expression of MMP2, MMP9, Col1A1, mir210, but did not change HIF-1α. Gallic acid decreased levels of leptin secreted by oral squamous cell carcinoma cells, accordingly with downregulation of p44/42 MAPK expression. Thus, gallic acid appears to break down neoplastic phenotype of oral squamous cell carcinoma cells by interfering with leptin pathway.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPathology: Research and Practicept_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherÁcido gálicopt_BR
dc.subject.otherCarcinoma de células escamosaspt_BR
dc.subject.otherCélulas - Proliferaçãopt_BR
dc.subject.otherMigração celularpt_BR
dc.subject.otherNeovascularizaçãopt_BR
dc.subject.otherApoptosept_BR
dc.titleGallic acid modulates phenotypic behavior and gene expression in oral squamous cell carcinoma cells by interfering with leptin pathwaypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0344033817301978?via%3Dihubpt_BR
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