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http://hdl.handle.net/1843/44725| Type: | Artigo de Periódico |
| Title: | Maternal obesity modulates both the renin–angiotensin system in mice dams and fetal adiposity |
| Authors: | Gabriela Cavazza Cerri Daisy Motta Santos João Marcus Oliveira Andrade Luiz Fernando de Rezende Robson Augusto Souza dos Santos Sergio Henrique Sousa Santos |
| Abstract: | Obesity is a chronic multifactorial disease and is currently a public health problem. Maternal obesity during pregnancy is more dangerous as it impairs the health of the mother and future generations. Obesity leads to several metabolic disorders. Since white adipose tissue is an endocrine tissue, obesity often leads to disordered secretion of inflammatory, glycemic, lipid and renin–angiotensin system (RAS) components. The RAS represents a link between obesity and its metabolic consequences. Therefore, our goal was to evaluate the possible changes caused by a high-fat diet in RAS-related receptor expression in the uterus and placenta of pregnant mice and determine the underlying effects of these changes in the fetuses’ body composition. Breeding groups were formed after obesity induction by high-fat (HF) diet. Dams and fetuses were euthanized on the 19th day of the gestational period. The HF diet effectively induced obesity, glucose intolerance and insulin resistance in mice. Fetuses born from HF dams showed increased body weight and adiposity. Both results were accompanied by increased AT1R expression in placenta and uterus together with increased angiotensin-converting enzyme expression in the uterus and a decreased expression of MAS1 in placenta of HF dams. These results suggest a link between RAS, maternal obesity induced by HF diet and the fetuses’ body adiposity. This new path now can be more thoroughly explored. |
| Subject: | Obesidade Angiotensina Sistema renina-angiotensina Gravidez Tecido adiposo |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.jnutbio.2020.108413 |
| URI: | http://hdl.handle.net/1843/44725 |
| Issue Date: | Oct-2020 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0955286320304459 |
| metadata.dc.relation.ispartof: | The Journal of Nutritional Biochemistry |
| Appears in Collections: | Artigo de Periódico |
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