Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44898
Type: Artigo de Periódico
Title: Sirtuins, brain and cognition: a review of resveratrol effects
Authors: Daniel Silva Moraes
Daniele Cristina Moreira
João Marcus Oliveira Andrade
Sergio Henrique Sousa Santos
Abstract: Sirtuins (SIRTs) are a protein family with high preservation degree among evolutionary scale. SIRTs are histone deacetylases regulatory enzymes of genetic material deeply involved in numerous physiological tasks including metabolism, brain function and aging. Mammals sirtuins comprise seven enzymatic components (SIRT1–SIRT7). The highest studied sirtuin is SIRT1, which plays an essential position in the prevention and evolution of neuro-disorders. Resveratrol (3,5,4-trihydroxystylbene) (RSV) is a polyphenol, which belongs to a family compounds identified as stilbenes, predominantly concentrated in grapes and red wine. RSV is the must studied Sirtuin activator and is used as food supplementary compound. Resveratrol exhibits strong antioxidant activity, reducing free radicals, diminishing quinone-reductase-2 activity and exerting positive regulation of several endogenous enzymes. Resveratrol is also able to inhibit pro-inflammatory factors, reducing the stimulation of the nuclear factor kB (NF-kB) and the release of endogenous cytokines. Resveratrol treatment can modulate multiple signaling pathway effectors related to programmed cell death, cell survival, and synaptic plasticity. In this context, the present review looks over news and the role of Sirtuins activation and resveratrol effects on modulating target genes, cognition and neurodegenerative disorders.
Subject: Sistema nervoso central
Cognição
Polifenóis
Fitonutrientes
Suplementos dietéticos
Radicais livres (Química) - Efeito fisiológico
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights: Acesso Aberto
metadata.dc.identifier.doi: https://doi.org/10.1016/j.ibror.2020.06.004
URI: http://hdl.handle.net/1843/44898
Issue Date: Dec-2020
metadata.dc.url.externa: https://www.sciencedirect.com/science/article/pii/S2451830120300194
metadata.dc.relation.ispartof: IBRO Reports
Appears in Collections:Artigo de Periódico

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