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http://hdl.handle.net/1843/45818| Type: | Artigo de Periódico |
| Title: | Biocompatibility and immunohistochemical evaluation of a new calcium silicate-based cement, bio-c pulpo |
| Authors: | Leopoldo Cosme Silva João Eduardo Gomes-Filho Francine Benetti Dal-Fabbro Vivien Thiemy Sakai Luciano Tavarez Angelo Cintra Edilson Ervolino Naiana Viana Viola |
| Abstract: | AimTo evaluate the inflammatory response andability to induce mineral deposition through histologi-cal and immunohistochemical analysis for osteocalcin(OCN), osteopontin (OPN) and bone sialoprotein (BSP)of a new calcium silicate-based cement, Bio-C Pulpo(Angelus), compared to white mineral trioxide aggre-gate (White MTA-Ang) (Angelus).MethodologyPolyethylene tubes containing Bio-CPulpo and White MTA-Ang as well as empty tubeswere implanted into the dorsal connective tissue of30 Wistar rats, which were arranged in five groupsaccording to the period of analysis: 7, 15, 30, 60and 90 days. After each experimental period, thetubes with surrounding tissue were removed and his-tologically processed to be analysed usinghaematoxylin–eosin and immunohistochemistry forthe detection of OCN, OPN and BSP. The data werestatistically analysed (Friedman’s test) at a 5% signifi-cance level.ResultsThe inflammatory response observed withBio-C Pulpo and White MTA-Ang was greater after 7and 15 days and decreased from 30 days onwards.No significant difference was found between the con-trol, Bio-C Pulpo and White MTA-Ang at the differentperiods of analysis (P>0.05). The immunolabellingfor OCN, OPN and BSP was more intense for Bio-CPulpo and White MTA-Ang after 60 and 90 days,but there was no difference between Bio-C Pulpo andWhite MTA-Ang at the different periods of analysis(P>0.05).ConclusionBio-C Pulpo is biocompatible andinduces immunolabelling of osteogenic markers suchas OCN, OPN and BSP similar to White MTA-Ang. |
| Subject: | Osteocalcin Osteopontin Materials testing Pulpotomy |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1111/iej.13052 |
| URI: | http://hdl.handle.net/1843/45818 |
| Issue Date: | 4-Dec-2018 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/iej.13052 |
| metadata.dc.relation.ispartof: | International Endodontic Journal |
| Appears in Collections: | Artigo de Periódico |
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