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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/51758
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dc.creatorRummenigge Oliveira Silvapt_BR
dc.creatorArmando da Silva Cunha Júniorpt_BR
dc.creatorBruna Lopes da Costapt_BR
dc.creatorFlávia Rodrigues da Silvapt_BR
dc.creatorCarolina Nunes da Silvapt_BR
dc.creatorMayara Rodrigues Brandão de Paivapt_BR
dc.creatorLays Fernanda Nunes Douradopt_BR
dc.creatorÂngelo Malachias de Souzapt_BR
dc.creatorAdriano Antunes de Souza Araújopt_BR
dc.creatorPaula Santos Nunespt_BR
dc.date.accessioned2023-04-10T20:02:46Z-
dc.date.available2023-04-10T20:02:46Z-
dc.date.issued2019-
dc.citation.volume568pt_BR
dc.citation.spage1pt_BR
dc.citation.epage14pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ijpharm.2019.118466pt_BR
dc.identifier.issn1873-3476pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/51758-
dc.description.resumoSome recent studies have shown that pirfenidone (PFD) has favorable results in the healing process of the cornea. However, PFD in solution exhibits short half-life after topical application, and in this context, a liquid crystal nanoparticle system containing PFD (PFD-LCNPs) was developed. The nanoparticles were characterized by transmission electron microscopy, atomic force microscopy, small angle X-ray diffraction and polarized light microscopy. The PFD-LCNPs had particle size and zeta potential of 247.3 nm and −33.60 mV (stores at 4 °C), respectively, and 257.5 nm and −46.00 mV (stored at 25 °C), respectively. The pH of the formulation was 6.9 and the encapsulation efficiency was 35.9%. The in vitro release profiles indicated that PFD sustained release from PFD-LCNPs for up to 12 h. In vitro study of ocular irritation (HET-CAM test) concluded that components of the formulation are well tolerated for ocular administration. Corneal re-epithelialization time after chemical burning was significantly reduced in rabbits treated with PFD-loaded LCNPs when compared to the group treated with a vehicle. In addition, the anti-inflammatory action of pirfenidone was observed by reducing myeloperoxidase activity (MPO) and inflammatory cells in the histology of the tissues of animals treated with PFD-LCNPs. These findings indicated that the PFD-LCNPs might have the potential for effective ocular drug delivery.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Pharmaceutics-
dc.rightsAcesso Abertopt_BR
dc.subjectOcular chemical burnspt_BR
dc.subjectPirfenidonept_BR
dc.subjectLiquid crystalline nanoparticlespt_BR
dc.subjectCorneapt_BR
dc.subjectWound healingpt_BR
dc.subject.otherQueimaduras químicaspt_BR
dc.subject.otherNanopartículaspt_BR
dc.subject.otherCórneapt_BR
dc.subject.otherCicatrização de feridaspt_BR
dc.titleTreatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidonept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S037851731930506Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4506-7570pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1161-8936pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3007-9795pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1382-2487pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6449-7904pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5287-455Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8703-4283pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3588-0178pt_BR
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