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http://hdl.handle.net/1843/52842| Type: | Artigo de Periódico |
| Title: | Physical exercise, obesity, inflammation and neutrophil extracellular traps (NETs): a review with bioinformatics analysis |
| Authors: | Berenilde Valéria de Oliveira Sousa Daniela Fernanda de Freitas Renato Sobral Monteiro Júnior Iara Heloisa Ramos Mendes Jaciara Neves Sousa Victor Hugo Dantas Guimarães Sérgio Henrique Sousa Santos |
| Abstract: | Neutrophil extracellular traps (NETs) represent an innate organism defense mechanism characterized by neutrophil release of intracellular material to capture any aggressor agent. Elevated NETs release is associated with increased inflammatory response and related diseases, such as obesity. Chronic physical training is one of the main strategies to treat and prevent obesity. The relationship between physical training and NETs is still under study. The present review, followed by a bioinformatics analysis, demonstrates the meaningful connection between physical exercise, obesity, and NETs. The bioinformatics indicated TNF-α as a leading gene after the ontological analysis followed by positive-interleukin-6 regulation, chemokines, and inflammatory response regulation. The main results pointed to a relevant regulatory effect of physical training on NETs release, indicating physical exercise as a possible therapeutic target on modulating NETs and inflammation. |
| Subject: | Exercícios físicos Obesidade Inflamação Neutrófilos Bioinformática |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1007/s11033-021-06400-2 |
| URI: | http://hdl.handle.net/1843/52842 |
| Issue Date: | 20-May-2021 |
| metadata.dc.url.externa: | https://link.springer.com/article/10.1007/s11033-021-06400-2 |
| metadata.dc.relation.ispartof: | Molecular Biology Reports |
| Appears in Collections: | Artigo de Periódico |
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