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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/53891
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dc.creatorGeneviève Marcelinpt_BR
dc.creatorAdaliene Versiani Matos Ferreirapt_BR
dc.creatorYuejun Liupt_BR
dc.creatorMichael Atlanpt_BR
dc.creatorJudith Aron-Wisnewskypt_BR
dc.creatorVéronique Pellouxpt_BR
dc.creatorYair Botbolpt_BR
dc.creatorMarc Ambrosinipt_BR
dc.creatorMagali Fradetpt_BR
dc.creatorChristine Rouaultpt_BR
dc.creatorCorneliu Hénégarpt_BR
dc.creatorJean-Sébastien Hulotpt_BR
dc.creatorChristine Poitoupt_BR
dc.creatorAdriana Torciviapt_BR
dc.creatorRaphael Nail-Barthelemypt_BR
dc.creatorJean-Christophe Bichetpt_BR
dc.creatorEmmanuel L. Gautierpt_BR
dc.creatorKarine Clémentpt_BR
dc.date.accessioned2023-05-24T19:37:06Z-
dc.date.available2023-05-24T19:37:06Z-
dc.date.issued2017-
dc.citation.volume25pt_BR
dc.citation.issue3pt_BR
dc.citation.spage673pt_BR
dc.citation.epage685pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.cmet.2017.01.010pt_BR
dc.identifier.issn1932-7420pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/53891-
dc.description.resumoObesity-induced white adipose tissue (WAT) fibrosis is believed to accelerate WAT dysfunction. However, the cellular origin of WAT fibrosis remains unclear. Here, we show that adipocyte platelet-derived growth factor receptor-a-positive (PDGFRa+) progenitors adopt a fibrogenic phenotype in obese mice prone to visceral WAT fibrosis. More specifically, a subset of PDGFRa+ cells with high CD9 expression (CD9high) originates pro-fibrotic cells whereas their CD9low counterparts, committed to adipogenesis, are almost completely lost in the fibrotic WAT. PDGFRa pathway activation promotes a phenotypic shift toward PDGFRa+ CD9high fibrogenic cells, driving pathological remodeling and altering WAT function in obesity. These findings translated to human obesity as the frequency of CD9high progenitors in omental WAT (oWAT) correlates with oWAT fibrosis level, insulin-resistance severity, and type 2 diabetes. Collectively, our data demonstrate that in addition to representing a WAT adipogenic niche, different PDGFRa+ cell subsets modulate obesity-induced WAT fibrogenesis and are associated with loss of metabolic fitness.pt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCell Metabolismpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectWhite adipose tissuept_BR
dc.subjectObesitypt_BR
dc.subjectFibrosispt_BR
dc.subject.otherTecido adiposo brancopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherFibrosept_BR
dc.titleA PDGFRα-Mediated switch toward CD9ʰᶦᵍʰ adipocyte progenitors controls obesity-induced adipose tissue fibrosispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1550413117300451?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9779-5529pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2256-8652pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8486-5591pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5463-6117pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2976-7566pt_BR
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