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http://hdl.handle.net/1843/54866| Type: | Artigo de Periódico |
| Title: | Chemical composition of Magonia pubescens essential oils and gamma-radiation effects on its constituents and cytotoxic activity in leukemia and breast cancer model |
| Authors: | Acácio Raphael Aguiar Moraes Karen Caroline Camargo Maria Olivia Mercadante Simões Vany Perpetua Ferraz Márcio Tadeu Pereira Fernanda Cristina Gontijo Evangelista Adriano de Paula Sabino Lucienir Pains Duarte Antônio Flávio de Carvalho Alcântara Grasiely Faria de Sousa |
| Abstract: | Magonia pubescens A. St.-Hil. is a Brazilian species often used in ethnopharmacology for wound and pain healing and seborrhea treatment. For the first time, essential oils (EOs) obtained from M. pubescens inflorescences were studied. The plant materials (Montes Claros, Brazil, 2018) were submitted to different gamma-radiation doses and their chemical compositions were analyzed by GC/MS and GC-FID. The cytotoxic activity of the EOs was evaluated against K562 and MDA-MB-231 cancer cell lines. A total of 30 components were identified, being 24 compounds detected for the first time in M. pubescens. The main obtained components were hotrienol (35.9 %), cis-linalool oxide (17.0 %) and trans-linalool oxide (10.2 %). The chemical composition of the EO was slightly affected by the applied radiation doses. Irradiated and non-irradiated EOs showed cytotoxic activity against both cell lines and the non-irradiated EO sample was the most active against the K562 cell lines (IC50=22.10±1.98). |
| Abstract: | Magonia pubescens A. St.-Hil. é uma espécie brasileira frequentemente utilizada em etnofarmacologia para cicatrização de feridas e dores e tratamento de seborreia. Pela primeira vez, foram estudados óleos essenciais (OEs) obtidos de inflorescências de M. pubescens. Os materiais vegetais (Montes Claros, Brasil, 2018) foram submetidos a diferentes doses de radiação gama e suas composições químicas foram analisadas por GC/MS e GC-FID. A atividade citotóxica dos OEs foi avaliada contra as linhagens celulares de câncer K562 e MDA-MB-231. Um total de 30 componentes foram identificados, sendo 24 compostos detectados pela primeira vez em M. pubescens. Os principais componentes obtidos foram hotrienol (35,9 %), óxido cis-linalool (17,0 %) e óxido trans-linalool (10,2 %). A composição química do OE foi levemente afetada pelas doses de radiação aplicadas. OEs irradiados e não irradiados apresentaram atividade citotóxica contra ambas as linhagens celulares e a amostra de OE não irradiado foi a mais ativa contra as linhagens celulares K562 (IC50=22,10±1,98). |
| Subject: | Sapindaceae Etnofarmacologia Óleos voláteis Raios gama |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1002/cbdv.202100094 |
| URI: | http://hdl.handle.net/1843/54866 |
| Issue Date: | Jun-2021 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202100094 |
| metadata.dc.relation.ispartof: | Chemistry & Biodiversity |
| Appears in Collections: | Artigo de Periódico |
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