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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56245
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dc.creatorMarise Margareth Sakuraguipt_BR
dc.creatorMarisa Narciso Fernandespt_BR
dc.creatorMarcelo Gustavo Paulinopt_BR
dc.creatorNaiara Elisabete da Silva e Souzapt_BR
dc.creatorDriele Tavarespt_BR
dc.creatorAna Paula Terezanpt_BR
dc.creatorEmanuele Pesentipt_BR
dc.creatorAlessandra Gianipt_BR
dc.creatorJoão Batista Fernandespt_BR
dc.creatorMarta Margarete Cestaript_BR
dc.date.accessioned2023-07-14T19:15:07Z-
dc.date.available2023-07-14T19:15:07Z-
dc.date.issued2019-
dc.citation.volume169pt_BR
dc.citation.spage18pt_BR
dc.citation.epage24pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.toxicon.2019.08.002pt_BR
dc.identifier.issn1879-3150pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56245-
dc.description.resumoThe cyanobacterium Radiocystis fernandoi has been frequently identified in cyanobacterial blooms in Brazil. Recently, R. fernandoi strain R28, which produces microcystin (MC)-RR and MC-YR, was isolated from the Furnas reservoir, Minas Gerais, Brazil. The present study evaluated the hematological variables and erythrocyte antioxidant responses, lipid peroxidation (LPO), and genotoxicity in a neotropical fish (Hoplias malabaricus) after acute and subchronic exposure to a crude extract (CE) of R. fernandoi strain R28. Acute exposure (12 or 96 h) consisted of a single intraperitoneal (i.p.) CE injection, and subchronic exposure consisted of one i.p. CE injection every 72 h for 30 days. After acute exposure, fish exhibited macrocytic anemia (12 h post-injection) followed by normocytic anemia (96 h post-injection). The increased activity of superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, and the glutathione level in the erythrocytes did not prevent oxidative stress, manifested as lipid peroxidation and elevated DNA damage after acute exposure. After subchronic exposure, the hematological variables recovered, and the absence of erythrocyte oxidative stress suggests possible modulation by other biological factors, including a possible decrease in MC uptake by the cells and/or increasing detoxification efficiency that precludes erythrocyte damage.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofToxiconpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAntioxidant enzymespt_BR
dc.subjectGenotoxicitypt_BR
dc.subjectHematologypt_BR
dc.subjectLipid peroxidationpt_BR
dc.subjectMicrocystinspt_BR
dc.subject.otherEnzimaspt_BR
dc.subject.otherCianobacteriapt_BR
dc.subject.otherHematologiapt_BR
dc.titleCrude extract of cyanobacterium Radiocystis fernandoi strain R28 induces anemia and oxidative stress in fish erythrocytespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0041010119304258pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9621-5695pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0464-6848pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6864-887Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9515-1930pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2524-8534pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2924-3327pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6064-966Xpt_BR
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