1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56280
Full metadata record
DC FieldValueLanguage
dc.creatorHipácia Werneck Gomespt_BR
dc.creatorGabriel Henrique Campolina Silvapt_BR
dc.creatorBruna T. Mariapt_BR
dc.creatorMaria C. Baratapt_BR
dc.creatorGermán A. B. Mahechapt_BR
dc.creatorRex A. Hesspt_BR
dc.creatorCleida Aparecida de Oliveirapt_BR
dc.date.accessioned2023-07-14T20:18:19Z-
dc.date.available2023-07-14T20:18:19Z-
dc.date.issued2020-
dc.citation.volume8pt_BR
dc.citation.issue5pt_BR
dc.citation.spage1375pt_BR
dc.citation.epage1386pt_BR
dc.identifier.doihttps://doi.org/10.1111/andr.12783pt_BR
dc.identifier.issn2047-2927pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56280-
dc.description.resumoBackground: Prostate cancer remains one of the most common cancers in men. Macrophages are thought to be important regulators in cancers, and their potential involvement in prostate cancer should not be overlooked. Therefore, the association between macrophages and the pre-tumorous changes in prostate epithelium during aging deserves further investigation. Objectives: We sought to investigate whether macrophages would be recruited into the prostate epithelium that display pathological lesions commonly found during aging. Materials and methods: Prostates of aging rats, with and without treatment with a combination of testosterone and estradiol, were examined for premalignant and malignant epithelial lesions. For comparison, prostates of castrated rats were also investigated. Results: Intraepithelial macrophages were found restricted to areas of premalignant and malignant lesions. An unprecedented interaction between macrophages and basal cells was observed in the aging pathological lesions. The intraepithelial macrophages were associated with autophagy, in contrast to those found after castration. In prostate lesions, the intraepithelial macrophages had TAM phenotype (CD68+/iNOS+/ CD206+/ARG+), denoting a possible involvement in cancer progression. However, M2 macrophages (CD68+/CD163+) were recruited into the epithelium after castration, possibly to phagocytize cells undergoing apoptosis. Discussion and conclusion: In conclusion, macrophages were recruited into the prostate epithelium and presented diverse phenotypes and morphology, consistent with changes reflected in the hormonal environment. Macrophages with the TAM phenotype were found restricted to areas of premalignant and malignant lesions in aging prostates, denoting a possible involvement in cancer progression. In contrast, M2 macrophages were found in the regressed epithelium after castration.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAndrologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAgingpt_BR
dc.subjectAutophagypt_BR
dc.subjectEpitheliumpt_BR
dc.subjectMacrophagept_BR
dc.subjectProstatept_BR
dc.subject.otherEnvelhecimentopt_BR
dc.subject.otherEpiteliopt_BR
dc.subject.otherMacrofagospt_BR
dc.subject.otherProstatapt_BR
dc.titleTumor-Associated Macrophages (TAM) are recruited to the aging prostate epithelial lesions and become intermingled with basal cellspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/andr.12783pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5243-8272pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4473-3340pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2907-0945pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2649-3563pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9610-7846pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.