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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56282
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dc.creatorMônica Morais Santospt_BR
dc.creatorHipácia Werneck Gomespt_BR
dc.creatorGabriel Henrique Campolina Silvapt_BR
dc.creatorLeticia C. Santospt_BR
dc.creatorGermán A. B. Mahechapt_BR
dc.creatorRex Hesspt_BR
dc.creatorCleida Aparecida de Oliveirapt_BR
dc.date.accessioned2023-07-14T20:23:01Z-
dc.date.available2023-07-14T20:23:01Z-
dc.date.issued2018-
dc.citation.volume159pt_BR
dc.citation.issue2pt_BR
dc.citation.spage723pt_BR
dc.citation.epage732pt_BR
dc.identifier.doihttps://doi.org/10.1210/en.2017-00773pt_BR
dc.identifier.issn0013-7227pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56282-
dc.description.resumoBesides androgens, estrogen signaling plays a key role in normal development and pathologies of the prostate. Irreversible synthesis of estrogens from androgens is catalyzed by aromatase. Interestingly, animals lacking aromatase do not develop cancer or prostatitis, whereas those with overexpression of aromatase and, consequently, high estrogen levels develop prostatitis and squamous metaplasia via estrogen receptor 1 (ERα). Even with this evidence, the aromatase expression in the prostate is controversial. Moreover, little is known about the occurrence of age-dependent variation of aromatase and its association with histopathological changes commonly found in advanced age, a knowledge gap that is addressed herein. For this purpose, the immunoexpression of aromatase was evaluated in the prostatic complex of young adult to senile Wistar rats. ERα was also investigated, to extend our understanding of estrogen responsiveness in the prostate. Moderate cytoplasmic immunoreactivity for aromatase was detected in the glandular epithelium. Eventually, some basal cells showed intense staining for aromatase. The expression pattern for aromatase appeared similar in the normal epithelium when young and senile rats were compared; this result was corroborated by Western blotting. Conversely, in senile rats, there was an increase in the frequency of basal cells intensely stained for aromatase, which appeared concentrated in areas of intraepithelial proliferation and prostatitis. These punctual areas also presented increased ERα positivity. Together, these findings suggest a plausible source for hormonal imbalance favoring estrogen production, which, by acting through ERα, may favor the development of prostatic lesions commonly found in advanced age.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEndocrinologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectProstatept_BR
dc.subjectEstrogen receptorpt_BR
dc.subjectAromatasept_BR
dc.subjectAgingpt_BR
dc.subjectBasal cellpt_BR
dc.subject.otherProstatapt_BR
dc.subject.otherEnvelhecimentopt_BR
dc.titleBasal cells show increased expression of aromatase and estrogen receptor α in prostate epithelial lesions of male aging ratspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://academic.oup.com/endo/article/159/2/723/4600203pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5157-159Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5243-8272pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4473-3340pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2907-0945pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2649-3563pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9610-7846pt_BR
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