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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57196
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dc.creatorRenata Crispim Batistapt_BR
dc.creatorCarlos Basílio Pinheiropt_BR
dc.creatorFabio da Silva Mirandapt_BR
dc.creatorMauricio Lanznasterpt_BR
dc.date.accessioned2023-07-31T11:50:02Z-
dc.date.available2023-07-31T11:50:02Z-
dc.date.issued2018-
dc.citation.volume2018pt_BR
dc.citation.issue5pt_BR
dc.citation.spage612pt_BR
dc.citation.epage616pt_BR
dc.identifier.doihttps://doi.org/10.1002/ejic.201701251pt_BR
dc.identifier.issn1099-0682pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57196-
dc.description.resumoThe motivation of this work was to probe whether coordination of esculetin to cobalt(III) could lead to a complex with the required properties to function as a redox-activated drug delivery platform, selective for hypoxic environments. The complex [Co(esc)(py2en)]ClO4·(CH3OH)2 (1) was obtained and fully characterized by CHN elemental analysis, single-crystal X-ray diffractometry, UV/Vis and fluorescence spectroscopy, and ESI mass spectrometry. The redox behavior of 1 was evaluated by cyclic and square wave voltammetry analyses in MeCN and PBS buffer, which revealed distinct potentials for the Co3+/Co2+ processes in aqueous and organic solutions. In PBS, the potential is within the accepted ideal range (–0.2 to –0.4 V vs. SHE) for reduction in biological systems. Thus, a selective release of the coumarin ligand in a hypoxic environment upon reduction was simulated by investigating reactions of 1 with sodium dithionite in argon-, air-, and O2-saturated atmospheres. An [O2]-dependent dissociation of esculetin was monitored over a 72 h period at 25 °C by UV/Vis spectroscopy and confirmed by fluorescence spectroscopy and ESI-MS data. These results provide strong evidence of a hypoxia-selective, redox-activated mechanism for the release of esculetin from this cobalt(III) complex.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Inorganic Chemistry-
dc.rightsAcesso Restritopt_BR
dc.subjectEsculetin–cobaltpt_BR
dc.subjectRedox-activated drug delivery platformpt_BR
dc.subject.otherCobaltopt_BR
dc.titleAn esculetin-cobalt(III) archetype for redox-activated drug delivery platforms with hypoxic selectivitypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejic.201701251pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8674-1779pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9977-242Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0477-0152pt_BR
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