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http://hdl.handle.net/1843/57197| Type: | Artigo de Periódico |
| Title: | The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1 |
| Authors: | Ludmila Maria Diniz Leroy João Alexandre Ribeiro Gonçalves Barbosa Gonzalo de Prat Gay Igor Polikarpov Carlos Basílio Pinheiro |
| Abstract: | Bovine papillomavirus proteins were extensively studied as a prototype for the human papillomavirus. Here, the crystal structure of the extended E2 DNA-binding domain of the dominant transcription regulator from the bovine papillomavirus strain 1 is described in the space group P3121. We found two protein functional dimers packed in the asymmetric unit. This new protein arrangement inside the crystal led to the reduction of the mobility of a previously unobserved loop directly involved in the protein-DNA interaction, which was then modeled for the first time. |
| Subject: | Papilomavírus |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE FÍSICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1002/prot.25773 |
| URI: | http://hdl.handle.net/1843/57197 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1002/prot.25773 |
| metadata.dc.relation.ispartof: | PROTEINS: Structure, Function, and Bioinformatics |
| Appears in Collections: | Artigo de Periódico |
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