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http://hdl.handle.net/1843/59242| Type: | Artigo de Periódico |
| Title: | Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions |
| Authors: | Fernando Marcos Dos Reis Adelina M. Reis |
| Abstract: | Angiotensin (Ang)-(1-7) is an active peptide formed from Ang I or Ang-(1-9) by multiple proteolytic steps involving angiotensin-converting enzyme (ACE) 1 and other peptidases, or by a single cleavage of Ang II catalyzed chiefly by ACE2. The effects of Ang-(1-7) are mediated by the G protein-coupled receptor Mas (or Mas1), encoded by the protooncogene MAS. The reproductive system expresses ACE2 quite abundantly and therefore is able to generate Ang-(1-7) using precursor peptides produced locally or taken from circulation. In several mammalian species, Ang-(1-7) stimulates ovarian follicle growth, oocyte maturation and ovulation. The peptide is found in human endometrium, mostly during the secretory phase of menstrual cycle when the uterus is receptive to embryo implantation. Rat models and human observational studies suggest that Ang-(1-7) is part of the maternal adaptive response to pregnancy and its deficiency is associated withpoor circulation in the placental bed.KnockoutmicerevealedarelevantparticipationofMas-mediatedstimulustothemaintenanceofnormalspermatogenesis,eventhoughtheanimalcanstillreproducewithoutit.In addition, thevasorelaxant effect ofAng-(1-7) participates inthephysiological mechanism of corpus cavernosum blood influx and penile erection. We conclude that preclinical evidence encourages the pursuit of treatments for female and male reproductive dysfunctions based on Mas agonists, starting with its natural ligand Ang-(1-7). |
| Subject: | Placenta Endometrio Ovarios |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1042/CS20200865 |
| URI: | http://hdl.handle.net/1843/59242 |
| Issue Date: | 2020 |
| metadata.dc.url.externa: | https://portlandpress.com/clinsci/article/134/22/2929/226965/Angiotensin-converting-enzyme-2-ACE2-angiotensin-1 |
| metadata.dc.relation.ispartof: | Clinical Science |
| Appears in Collections: | Artigo de Periódico |
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