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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59242
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dc.creatorFernando Marcos Dos Reispt_BR
dc.creatorAdelina M. Reispt_BR
dc.date.accessioned2023-10-05T23:04:17Z-
dc.date.available2023-10-05T23:04:17Z-
dc.date.issued2020-
dc.citation.volume134pt_BR
dc.citation.issue22pt_BR
dc.citation.spage2929pt_BR
dc.citation.epage2941pt_BR
dc.identifier.doihttps://doi.org/10.1042/CS20200865pt_BR
dc.identifier.issn1470-8736pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59242-
dc.description.resumoAngiotensin (Ang)-(1-7) is an active peptide formed from Ang I or Ang-(1-9) by multiple proteolytic steps involving angiotensin-converting enzyme (ACE) 1 and other peptidases, or by a single cleavage of Ang II catalyzed chiefly by ACE2. The effects of Ang-(1-7) are mediated by the G protein-coupled receptor Mas (or Mas1), encoded by the protooncogene MAS. The reproductive system expresses ACE2 quite abundantly and therefore is able to generate Ang-(1-7) using precursor peptides produced locally or taken from circulation. In several mammalian species, Ang-(1-7) stimulates ovarian follicle growth, oocyte maturation and ovulation. The peptide is found in human endometrium, mostly during the secretory phase of menstrual cycle when the uterus is receptive to embryo implantation. Rat models and human observational studies suggest that Ang-(1-7) is part of the maternal adaptive response to pregnancy and its deficiency is associated withpoor circulation in the placental bed.KnockoutmicerevealedarelevantparticipationofMas-mediatedstimulustothemaintenanceofnormalspermatogenesis,eventhoughtheanimalcanstillreproducewithoutit.In addition, thevasorelaxant effect ofAng-(1-7) participates inthephysiological mechanism of corpus cavernosum blood influx and penile erection. We conclude that preclinical evidence encourages the pursuit of treatments for female and male reproductive dysfunctions based on Mas agonists, starting with its natural ligand Ang-(1-7).pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinical Sciencept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAngiotensin 1-7pt_BR
dc.subjectMASpt_BR
dc.subjectACE2pt_BR
dc.subjectOvarypt_BR
dc.subjectEndometriumpt_BR
dc.subjectPlacentapt_BR
dc.subject.otherPlacentapt_BR
dc.subject.otherEndometriopt_BR
dc.subject.otherOvariospt_BR
dc.titleAngiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functionspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://portlandpress.com/clinsci/article/134/22/2929/226965/Angiotensin-converting-enzyme-2-ACE2-angiotensin-1pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0138-9612pt_BR
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