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http://hdl.handle.net/1843/59643| Type: | Artigo de Periódico |
| Title: | Sinonasal melanoma: a systematic review of the prognostic factors |
| Authors: | Flavia Sirotheau Correa Pontes Lucas Lacerda de Souza Ciro Dantas Soares Felipe Paiva Fonseca Bruno Augusto Benevenuto de Andrade Hélder Antônio Rebelo Pontes De Abreu Fernandes Rodrigues Do Nascimento Vasconcelos Corrêa |
| Abstract: | The objective was to evaluate the available published data on sinonasal melanoma and analyse its clinical features, treatment modalities, and prognostic factors. An electronic search was undertaken in March 2018 in multiple databases. Eligibility criteria included publications with sufficient clinical, histological, and immunohistochemical information to confirm the diagnosis. Seventy-three publications (439 cases) were included. The lesion was more prevalent in females than in males. There was a higher prevalence in the seventh and eighth decades of life. The lesions mainly presented as epistaxis and commonly involved the nasal cavity. Age (>67.6 years; P=0.0012), primary location (middle turbinate; P=0.0112), disease stage (advanced disease stage; P=0.0026), treatment (radiotherapy; P=0.0111), recurrence (recurrence presented; P=0.0137), and distant metastasis (distant metastasis presented; P=0.0011) were independently associated with a lower survival rate. Recurrence was significantly correlated with age (>67.6 years; P=0.0021), sex (males tended to present a higher recurrence rate than females; P=0.0051), disease stage (stages III and IV presented a higher recurrence rate than stages I and II; P=0.0331), and histological type (amelanotic lesions presented a higher index of recurrence than melanotic lesions; P=0.0095). In conclusion, sinonasal melanoma is a neoplasm with a poor prognosis, presenting a 30.69% possibility of survival after 5 years. |
| Subject: | Melanoma, amelanotic Recurrence Paranasal sinuses Survival Prognosis Therapeutics Nose Epistaxis Neoplasm metastasis |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.ijom.2019.11.001 |
| URI: | http://hdl.handle.net/1843/59643 |
| Issue Date: | May-2020 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0901502719313992?via%3Dihub |
| metadata.dc.relation.ispartof: | International Journal of Oral and Maxillofacial Surgery |
| Appears in Collections: | Artigo de Periódico |
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