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Type:	Artigo de Periódico
Title:	Lung function six months after severe covid-19: does time, in fact, heal all wounds?
Authors:	Daniel Cruz Bretas Carolina Coimbra Marinho Arnaldo Santos Leite Eliane Viana Mancuzo Tarciane Aline Prata Bruno Horta Andrade Jacqueline Das Graças Ferreira Oliveira Aline Priscila Batista George Luiz Lins Machado Coelho Valéria Maria Augusto
Abstract:	Background: COVID-19 has been associated with persistent symptoms and functional changes, especially in those surviving severe disease.Methods: We conducted a prospective multicenter study in patients with severe COVID-19 to determine respiratory sequelae. Patients were stratified into two groups: ward admission (WA) and intensive care unit (ICU) admission. In each follow-up visit, the patients where inquired about cough and dyspnea, and performed spirometry, lung volumes, carbon mon oxide diffusion capacity (DLCO), 6-minute walk test (6MWT), and respiratory muscle strength (MIP and MEP). Results of pulmonary function tests at 45 days and 6 months after hospital admission were compared using paired analysis.Results: 211 patients were included, 112 in WA and 99 in ICU. Dyspnea persisted in 64.7% in the WA and 66.7% in the ICU group after 6 months. Lung function measures showed signifi cant improvement between 45 days and 6 months, both in WA and ICU groups in VC, FVC,FEV1, total lung capacity, and 6MW distance measures. The improvement in the propor tions of the altered functional parameters was significant in the ICU group for VC (44.2% 45 d; 20.8% 6 m; p = 0,014), FVC (47.6% 45 d; 28% 6 m; p = 0,003), FEV1 (45.1% 45 d; 28% 6 m;p = 0,044), DLCO (33.8% 45 d; 7.7% 6 m; p < 0,0001).Conclusion: Six months follow-up of patients with the severe forms of COVID-19 showed significant improvement in the lung function measures compared to 45 days post hospital dis charge. The difference was more evident in those requiring ICU admission.
Subject:	COVID-19 Respiratory Function Tests Follow-Up Studies Post-Acute COVID-19 Syndrome
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE CLÍNICA MÉDICA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.bjid.2022.102352
URI:	http://hdl.handle.net/1843/60102
Issue Date:	2022
metadata.dc.url.externa:	doi:10.1016/j.bjid.2022.102352
metadata.dc.relation.ispartof:	The Brazilian Journal of Infectious Diseases
Appears in Collections:	Artigo de Periódico

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