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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61314
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dc.creatorAna Delia Pinzón Garcíapt_BR
dc.creatorPuebla Cassini Vieirapt_BR
dc.creatorCyntia Cabral Ribeiropt_BR
dc.creatorCarlos Eduardo de Matos Jensenpt_BR
dc.creatorLuciola Silva Barcelospt_BR
dc.creatorMaría Esperanza Cortés Segurapt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.date.accessioned2023-11-23T18:43:56Z-
dc.date.available2023-11-23T18:43:56Z-
dc.date.issued2017-10-
dc.citation.volume105pt_BR
dc.citation.issue7pt_BR
dc.citation.spage1938pt_BR
dc.citation.epage1949pt_BR
dc.identifier.doihttps://doi.org/10.1002/jbm.b.33724pt_BR
dc.identifier.issn1552-4981pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61314-
dc.description.resumoThe present work demonstrated an efficient cutaneous wound healing using Bixin-loaded polycaprolactone (PCL) nanofibers as a controlled delivery system. The influence of Bixin (Bix) content on PCL nanofiber, Bix-PCL1(2.5% w/w bix) and Bix-PCL2 (12.5% w/w bix) formation was investigated using electrical conductivity, attenuated total reflectance infrared spectroscopy, X-ray diffraction, thermal analysis, and scanning electronic microscopy. The results showed that a greater bixin concentration resulted in higher polymeric solution electrical conductivity. Moreover, higher polymeric solution electrical conductivity provides lower nanofibers in terms of average diameter than pure PCL nanofibers. In vitro release was largely governed by a diffusion-controlled mechanism. The initial Bixin release domain showed a burst release over the first 10 hours where approximately 30% and 40% of Bixin was released from Bix-PCL1 and Bix-PCL2 nanofibers, respectively. The second kinetic domain was comprised of a continuous and slow Bixin release that led to almost 100% of the Bixin being released within 14 days. The results on excisional wound model in induced diabetic mice indicated that the low concentration of Bixin released from loaded Bix-PCL nanofibers maintain the biological activity of Bixin and is efficient in accelerating the wound healing as well as in reducing the scar tissue area compared with pure PCL nanofibers. Therefore, soft material Bixin-loaded PCL nanofibers are a promising candidate for use in wound dressing.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Biomedical Materials Research Part B: Applied Biomaterialspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBixinpt_BR
dc.subjectPolymeric nanofiberpt_BR
dc.subjectWound healingpt_BR
dc.subjectDiabetes mellituspt_BR
dc.subjectPolycaprolactone (PCL)pt_BR
dc.subject.otherCicatrização de feridaspt_BR
dc.subject.otherDiabetespt_BR
dc.subject.otherCarotenoidespt_BR
dc.subject.otherCondutividade elétricapt_BR
dc.subject.otherEspectroscopia de infravermelhopt_BR
dc.subject.otherRaios X - Difraçãopt_BR
dc.subject.otherAnálise térmicapt_BR
dc.subject.otherMicroscopia eletrônica de varredurapt_BR
dc.titleEfficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33724pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8876-4907pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9066-414Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0560-8491pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
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