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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/61352
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Campo DCValorIdioma
dc.creatorAna Delia Pinzón Garcíapt_BR
dc.creatorLaura Alejandra Ariza Orellanopt_BR
dc.creatorMarcela Guimarães Takahashi de Lazaript_BR
dc.creatorPaula Peixoto Campospt_BR
dc.creatorMaría Esperanza Cortés Segurapt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.date.accessioned2023-11-24T15:25:57Z-
dc.date.available2023-11-24T15:25:57Z-
dc.date.issued2018-10-
dc.citation.volume106pt_BR
dc.citation.spage363pt_BR
dc.citation.epage372pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2018.06.144pt_BR
dc.identifier.issn1950-6007pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61352-
dc.description.resumoAssociations between obesity, diabetes type II, and steatosis have long been recognized. However, a pharmacotherapy that acts in a multifactorial manner controlling the interactions between these conditions is not available. A variety of natural plants, functional fatty acids, and other natural dietary compounds have been used in various anti-obesity products. We investigated the effects of oral administration of an antioxidant carotenoid pigment Bixin and Bixin: β-Cyclodextrin in an obese murine model. C57BL/6 male mice (4–5 weeks) received standard diet (2.18 kcal per 1 g) (CT) and high-fat diet (4.38 kcal per 1 g) (CT/OB, BIX and BIX/βCD) (n = 10 per group). After 16 weeks, the BIX and BIX/βCD were treated by gavage (100 μL day-1) for six weeks, with water (CT and CT/OB groups) and (50 mg kg-1 day-1), Bixin (BIX group) or Bix: β-CD (BIX/βCD). Body weight, Lee's Index, adiposity, CHT, TG, CHT/HDL-c, glucose levels (metabolic markers) and, liver markers (AST and ALT) were determined. All metabolic and liver parameters exhibited down-regulation after oral administration of BIX and BIX/βCD. Particularly relevant was Lee’s Index and adiposity in BIX- and BIX/βCD-treated groups (339.18 g/cm -BIX and 327.58 g/cm -BIX/βCD vs. 360.68 g/cm -CT/OB animals), this finds associated with the insulin sensitivity test, showed a clear association between reduction of adipose tissue and decrease of peripherical insulin resistant. In conclusion, our study suggested that the oral administration of the Bixin and Bix: β-CD inclusion compound improved the metabolic parameters evaluate in obese mice, being more palatable and hepatoprotective.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBiomedicine & Pharmacotherapypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBixinpt_BR
dc.subjectInclusion compoundpt_BR
dc.subjectDiabetes type IIpt_BR
dc.subjectObesitypt_BR
dc.subjectSteatosispt_BR
dc.subject.otherCarotenoidespt_BR
dc.subject.otherDiabetespt_BR
dc.subject.otherObesidade - Tratamentopt_BR
dc.subject.otherDegeneração gordurosapt_BR
dc.subject.otherAgentes hipoglicemicospt_BR
dc.subject.otherHipolipemiantespt_BR
dc.subject.otherMatéria médica vegetalpt_BR
dc.subject.otherCiclodextrinaspt_BR
dc.titleEvidence of hypoglycemic, lipid-lowering and hepatoprotective effects of the bixin and bixin: β-CD inclusion compound in high-fat-fed obese micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332218309703pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8876-4907pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1509-8488pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9912-9044pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2016-2210pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0560-8491pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
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