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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/61464
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Campo DCValorIdioma
dc.creatorMariana S. de Oliveirapt_BR
dc.creatorSávio Morato Lacerda Gontijopt_BR
dc.creatorMarina S. Teixeirapt_BR
dc.creatorKarina Imaculada Rosa Teixeirapt_BR
dc.creatorJacqueline Aparecida Takahashipt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorMaría Esperanza Cortés Segurapt_BR
dc.date.accessioned2023-11-28T18:53:30Z-
dc.date.available2023-11-28T18:53:30Z-
dc.date.issued2018-
dc.citation.volume12pt_BR
dc.citation.issue2pt_BR
dc.citation.spage135pt_BR
dc.citation.epage146pt_BR
dc.identifier.doihttps://doi.org/10.5935/2446-4775.20180013pt_BR
dc.identifier.issn2446-4775pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61464-
dc.description.resumoIn this study, we isolated and characterized dichloromethane and hexane extracts, complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), of Schinus terebinthifolius fruits. Such complexation may be useful in the formulation of herbal medicines, by improving solubility, or increasing stability by reducing the loss of volatile compounds. The cytotoxicity in osteoblasts, antifungal against Malassezia furfur and antitumor activities were evaluated in Caco-2 cells. The antifungal activity of the extracts and the essential oil in natura or complexed with HP-β-CD against the fungus M. furfur was evaluated by agar diffusion methods and quantitatively by inhibitory concentration (IC). All samples inhibited fungus growth and, when complexed with HP-β-CD, the IC was reduced by 50%. Osteoblast cell viability was not affected by the presence of extracts and oil. The antitumor activity of the extract in dichloromethane was evaluated using Caco-2 cells. The results demonstrated significant reduction in cell viability in the presence of the extract, which makes it a promising candidate for cancer treatment.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista Fitospt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSchinus terebinthifoliuspt_BR
dc.subjectAntifungalpt_BR
dc.subjectAntitumorpt_BR
dc.subjectCyclodextrinpt_BR
dc.subjectMalassezia furfurpt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.subject.otherAtividade antifúngicapt_BR
dc.subject.otherAntimicóticospt_BR
dc.subject.otherCiclodextrinaspt_BR
dc.subject.otherAroeira-vermelhapt_BR
dc.subject.otherEssencias e óleos essenciais - Uso terapêuticopt_BR
dc.subject.otherMatéria médica vegetalpt_BR
dc.subject.otherDiclorometanopt_BR
dc.titleChemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruitpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.arca.fiocruz.br/handle/icict/27868pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7803-4345pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8831-1609pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0560-8491pt_BR
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