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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61859
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dc.creatorMariana Lourenço Freirept_BR
dc.creatorDaniel Moreira Avelarpt_BR
dc.creatorGlaucia Fernandes Cotapt_BR
dc.creatorLindicy Leidicy Alvespt_BR
dc.creatorCarolina Senra de Souzapt_BR
dc.creatorJuliana Wilke Salibapt_BR
dc.creatorVerônica Fariapt_BR
dc.creatorMariana Junqueira Pedraspt_BR
dc.creatorNara de Oliveira Carvalhopt_BR
dc.creatorGláucia Queiroz Andradept_BR
dc.creatorAna Rabellopt_BR
dc.date.accessioned2023-12-07T22:51:50Z-
dc.date.available2023-12-07T22:51:50Z-
dc.date.issued2022-06-16-
dc.citation.volume17pt_BR
dc.citation.issue6pt_BR
dc.citation.spage1pt_BR
dc.citation.epage13pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal. pone.0269997pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61859-
dc.description.resumoA rapid and accurate diagnosis is a crucial strategy for containing the coronavirus disease (COVID-19) pandemic. Considering the obstacles to upscaling the use of RT–qPCR, rapid tests based on antigen detection (Ag-RDT) have become an alternative to enhance mass testing, reducing the time for a prompt diagnosis and virus spreading. However, the performances of several commercially available Ag-RDTs have not yet been evaluated in several countries. Here, we evaluate the performance of eight Ag-RDTs available in Brazil to diagnose COVID-19. Patients admitted to tertiary hospitals with moderate or mild COVID-19 symptoms and presenting risk factors for severe disease were included. The tests were performed using a masked protocol, strictly following the manufacturer’s recommendations and were compared with RT–qPCR. The overall sensitivity of the tests ranged from 9.8 to 81.1%, and specificity greater than 83% was observed for all the evaluated tests. Overall, slight or fair agreement was observed between Ag-RDTs and RT–PCR, except for the Ag-RDT COVID-19 (Acro Biotech), in which moderate agreement was observed. Lower sensitivity of Ag-RDTs was observed for patients with cycle threshold > 25, indicating that the sensitivity was directly affected by viral load, whereas the effect of the disease duration was unclear. Despite the lower sensitivity of Ag-RDTs compared with RT–qPCR, its easy fulfillment and promptness still justify its use, even at hospital admission. However, the main advantage of Ag-RDTs seems to be the possibility of increasing access to the diagnosis of COVID-19 in patients with a high viral load, allowing immediate clinical management and reduction of infectivity and community transmission.pt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentHCL - HOSPITAL DAS CLINICASpt_BR
dc.publisher.departmentMEDICINA - FACULDADE DE MEDICINApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPlos Onept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAntigen rapid testspt_BR
dc.subjectCOVID-19pt_BR
dc.subjectBrazilpt_BR
dc.subject.otherTestes de Diagnóstico Rápidopt_BR
dc.subject.otherTeste para COVID-19pt_BR
dc.subject.otherBrasilpt_BR
dc.titlePerformance differences among commercially available antigen rapid tests for COVID-19 in Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269997pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0538-7403pt_BR
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