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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/63084
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dc.creatorCamilla Rayanede-paulapt_BR
dc.creatorMaria da Gloria Rodrigues-machadopt_BR
dc.creatorGiselle Santos Magalhãespt_BR
dc.creatorNulma Souto Jentzschpt_BR
dc.creatorCamila Figueredo Botelhopt_BR
dc.creatorCleonice de Carvalho Coelho Motapt_BR
dc.creatorTatiane Moisés Murçapt_BR
dc.creatorLidiana Fatima Correa Ramalhopt_BR
dc.creatorTimothy c. Tanpt_BR
dc.creatorCarolina Andrade Braganca Capuruçopt_BR
dc.date.accessioned2024-01-18T20:41:14Z-
dc.date.available2024-01-18T20:41:14Z-
dc.date.issued2018-
dc.citation.volume110pt_BR
dc.citation.issue3pt_BR
dc.citation.spage231pt_BR
dc.citation.epage239pt_BR
dc.identifier.doi10.5935/abc.20180052pt_BR
dc.identifier.issn0066782Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/63084-
dc.description.resumoBackground: Despite significant advances in understanding the pathophysiology and management of asthma, some of systemic effects of asthma are still not well defined.Objectives: To compare heart function, baseline physical activity level, and functional exercise capacity in young patients with mild-to-moderate asthma and healthy controls.Methods: Eighteen healthy (12.67 ± 0.39 years) and 20 asthmatics (12.0 ± 0.38 years) patients were enrolled in the study. Echocardiography parameters were evaluated using conventional and tissue Doppler imaging (TDI).Results: Although pulmonary acceleration time (PAT) and pulmonary artery systolic pressure (PASP) were within normal limits, these parameters differed significantly between the control and asthmatic groups. PAT was lower (p < 0.0001) and PASP (p < 0.0002) was higher in the asthma group (114.3 ± 3.70 ms and 25.40 ± 0.54 mmHg) than the control group (135.30 ± 2.28 ms and 22.22 ± 0.40 mmHg). The asthmatic group had significantly lower early diastolic myocardial velocity (E’, p = 0.0047) and lower E’ to late (E’/A’, p = 0.0017) (13.75 ± 0.53 cm/s and 1.70 ± 0.09, respectively) compared with control group (15.71 ± 0.34 cm/s and 2.12 ± 0.08, respectively) at tricuspid valve. In the lateral mitral valve tissue Doppler, the asthmatic group had lower E’ compared with control group (p = 0.0466; 13.27 ± 0.43 cm/s and 14.32 ± 0.25 cm/s, respectively), but there was no statistic difference in the E’/A’ ratio (p = 0.1161). Right isovolumetric relaxation time was higher (p = 0.0007) in asthmatic (57.15 ± 0.97 ms) than the control group (52.28 ± 0.87 ms), reflecting global myocardial dysfunction. The right and left myocardial performance indexes were significantly higher in the asthmatic (0.43 ± 0.01 and 0.37 ± 0.01, respectively) compared with control group (0.40 ± 0.01 and 0.34 ± 0.01, respectively) (p = 0.0383 and p = 0.0059, respectively). Physical activity level, and distance travelled on the six-minute walk test were similar in both groups.Conclusion: Changes in echocardiographic parameters, evaluated by conventional and TDI, were observed in mild-to-moderate asthma patients even with normal functional exercise capacity and baseline physical activity level. Our results suggest that the echocardiogram may be useful for the early detection and evoluation of asthma-induced cardiac changes.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArquivos Brasileiros de Cardiologia-
dc.rightsAcesso Abertopt_BR
dc.subjectDyspneapt_BR
dc.subjectEchocardiography, Dopplerpt_BR
dc.subjectAsthmapt_BR
dc.subjectVascular Remodelingpt_BR
dc.subjectVentricular Dysfunctionpt_BR
dc.subject.otherDyspneapt_BR
dc.subject.otherEchocardiography, Dopplerpt_BR
dc.subject.otherAsthmapt_BR
dc.subject.otherVascular Remodelingpt_BR
dc.subject.otherVentricular Dysfunctionpt_BR
dc.titleEchocardiographic assessment of ventricular function in young patients with asthmapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://doi.org/10.5935/abc.20180052pt_BR
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