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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/63427
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dc.creatorKelen Jorge Rodrigues da Costa Nunespt_BR
dc.creatorAlfonso Gala Garcíapt_BR
dc.creatorJoel Jose Passospt_BR
dc.creatorVagner Rodrigues Santospt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorCélia Regina Moreira Lanzapt_BR
dc.creatorMaría Esperanza Cortés Segurapt_BR
dc.date.accessioned2024-01-26T17:12:15Z-
dc.date.available2024-01-26T17:12:15Z-
dc.date.issued2019-
dc.citation.volume376pt_BR
dc.citation.spage221pt_BR
dc.citation.epage231pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00441-018-2970-3pt_BR
dc.identifier.issn1432-0878pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/63427-
dc.description.resumoTestosterone (T) has been suggested as a promising agent in the bone osteointegration when incorporated in a bioceramic/polymer combination for the local application. The objective of this study was to evaluate the activity of a testosterone composite of poly (lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL), and biphasic calcium phosphate (BCP) as a strategy for enhancing its osteogenic effect and to evaluate tissue response to the composite implantation. PLGA/PCL/BCP/T and PLGA/PCL/BCP composites were prepared and characterized using thermal analysis. Composite morphology and surface characteristics were assessed by SEM and EDS. The evaluations of in vitro effects of testosterone composite on osteoblasts viability, alkaline phosphatase activity, collagen production, osteocalcin concentration, quantification of mineralization, and nitric oxide concentration, after 7, 14, and 21 days. Testosterone was successfully incorporated and composites showed a homogeneously distributed porous structure. The PLGA/PCL/BCP/T composite had a stimulatory effect on osteoblastic activity on the parameters evaluated, except to nitric oxide production. After 60 days, the PLGA/PCL/BCP/T composite showed no chronic inflammatory infiltrate, whereas the PLGA/PCL/BCP composite showed mild chronic inflammatory infiltrate. Angiogenesis, cellular adsorption, and fibrous deposit were observed on the surfaces of implanted composites. The composites in combination with testosterone can be exploited to investigate the use of this scaffold for bone integration.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCell and Tissue Researchpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectTestosteronept_BR
dc.subjectBone formationpt_BR
dc.subjectCalcium phosphatept_BR
dc.subjectCeramic compositept_BR
dc.subjectMineralizationpt_BR
dc.subject.otherTestosteronapt_BR
dc.subject.otherFosfato de cálciopt_BR
dc.subject.otherBiomineralizaçãopt_BR
dc.subject.otherOssos - Crescimentopt_BR
dc.subject.otherOsseointegraçãopt_BR
dc.titleTestosterone improves the osteogenic potential of a composite in vitro and in vivopt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s00441-018-2970-3pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3934-1094pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5370-4867pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5893-2597pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0560-8491pt_BR
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