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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/63431
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dc.creatorStefânia Sales de Oliveira Santospt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorMarcelo Gomes Spezialipt_BR
dc.date.accessioned2024-01-26T17:58:21Z-
dc.date.available2024-01-26T17:58:21Z-
dc.date.issued2020-
dc.citation.volume124pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.eurpolymj.2020.109490pt_BR
dc.identifier.issn0014-3057pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/63431-
dc.description.resumoThis paper describes the preparation and characterization of a versatile Losartan-controlled-release material based on a functionalized cellulosic matrix grafted with the ionic liquid, [(MeO)3Sipmim][Cl]: 1–(trimethoxysilylpropyl)–3–methylimidazolium Chloride. A silanized ionic liquid was used as a solvent and a surface modification agent at the same time, allowing higher anionic drug loading capacity. The anionic Losartan drug release kinetics were evaluated as a model. The Losartan release was made using two distinct media, one at pH 7.4 and the other at 3.0 to simulate blood and stomach pH, respectively. Higher Losartan release-rate 88% at blood pH after 1085 min in comparison with 84% at stomach pH, after 330 min was attained. The higher Losartan release profile in acid pH compared with neutral pH could be associated to the hydrolysis of Si-O bond from the ionic liquid, with the acidic medium acting as a catalyst. This cellulosic matrix modified with ionic liquid showed promising for applications over a wide range of pH-controlled-release systems.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Polymer Journalpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectpH-dependentpt_BR
dc.subjectSilanizationpt_BR
dc.subjectLosartanpt_BR
dc.subjectDesorptionpt_BR
dc.subjectKorsmeyer – Peppas kinetic modelpt_BR
dc.subjectWeibull kinetic modelpt_BR
dc.subject.otherQuímicapt_BR
dc.subject.otherTecnologia de liberação controladapt_BR
dc.subject.otherAgentes hipotensorespt_BR
dc.subject.otherCinética quimicapt_BR
dc.subject.otherQuímica de superfíciept_BR
dc.subject.otherCelulose - Químicapt_BR
dc.titleVersatile grafted microcrystalline cellulose with ionic liquid as new Losartan-controlled release materialpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0014305719320543pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3572-9670pt_BR
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