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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/64884
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dc.creatorLeonardo Campos Zanelattopt_BR
dc.creatorPatrícia Benites Gonçalves da Silvapt_BR
dc.creatorDaniele Sartoript_BR
dc.creatorSandra Lepript_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorMário Sérgio Mantovanipt_BR
dc.date.accessioned2024-02-28T17:45:36Z-
dc.date.available2024-02-28T17:45:36Z-
dc.date.issued2016-
dc.citation.volume39pt_BR
dc.citation.issue2pt_BR
dc.citation.spage270pt_BR
dc.citation.epage278pt_BR
dc.identifier.doihttps://doi.org/10.1590/1678-4685-GMB-2015-0184pt_BR
dc.identifier.issn1678-4685pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/64884-
dc.description.resumoThe identification of antitumoral substances is the focus of intense biomedical research. Two structural analogues of thalidomide, LNO3 and L3, are two synthetic compounds that might possess such antitumor properties. We evaluated the toxicological effects of these substances, including cytotoxicity, genotoxicity and induction of apoptosis in HTC cells. Additionally, the production of free radicals (nitric oxide and superoxide) was investigated, and the expression of caspases genes 3, 8, and 9 were determined by RT-qPCR. The compounds exhibited cytotoxic effects that resulted in inhibited cell proliferation. LNO3 showed to be more effective and toxic than L3 in all assays. LNO3 stimulated the release of NO and superoxide, which was accompanied by the formation of peroxynitrite. Apoptosis was induced in a dose-dependent manner by both compounds; however, the expression of caspases 3, 8 and 9 was unchanged. These results suggested that L3 and LNO3 possess antiproliferative and pro-apoptotic effects in HTC cells. Additionally, although they exhibited cytotoxicity, L3 and LNO3 might be useful coadjuvants in tumor treatment studies.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofGenetics and Molecular Biologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectNitric oxide donating drugpt_BR
dc.subjectNitric oxidept_BR
dc.subjectFree radical scavengingpt_BR
dc.subjectApoptosispt_BR
dc.subjectAntiproliferative activitypt_BR
dc.subjectThalidomide analoguespt_BR
dc.subject.otherBioquímicapt_BR
dc.subject.otherQuímicapt_BR
dc.subject.otherÓxido nítricopt_BR
dc.subject.otherReações de radicais livrespt_BR
dc.subject.otherApoptosept_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.titleLNO3 and L3 are associated with antiproliferative and pro-apoptotic action in hepatoma cellspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/gmb/a/VSCtR4XRPdmK7Ydk8xfwS4Q/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9091-0766pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0465-9932pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3479-645Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5268-6508pt_BR
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