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Type:	Artigo de Periódico
Title:	Preemptive analgesia in dental implant surgery: a systematic review and meta-analysis of randomized controlled trials
Authors:	Gustavo Henrique Mattos Pereira Carolina Castro Martins Rafael Paschoal Esteves Lima Raquel Alvarenga Brant Luis Otavio de Miranda Cota Fernando de Oliveira Costa
Abstract:	Background To assess the effectiveness of preemptive analgesia in dental implant surgery in randomized controlled trials (RCTs). Material and Methods The present study was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and registered in PROSPERO database CRD42020168757. A search without restrictions regarding language or date of publication was conducted in six databases and gray literature. A random effect meta-analysis compared the efficacy of preemptive analgesia compared to placebo through pooled OR and 95%CI. The interpretation of results followed the certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach together with the magnitude of the effect according to GRADE guidelines. Results Four studies were included in the review and three were incorporated into the meta-analysis. All studies demonstrated that preemptive analgesia contributed to a significant improvement in the postoperative pain control. However, the overall pooled standard mean difference (SMD) showed that preemptive analgesia had small effects compared to placebo in reducing pain (SMD: -0.45; IC: -0.83; -0.08) with low certainty of the evidence. Our meta-analysis showed that the magnitude of the effect was bigger six to eight hours after the surgery (large effect), compared to the time of one to two hours after the surgery (small effect). Conclusions Preemptive analgesia may have a positive effect in reducing pain compared to not using preemptive medication, but the evidence is very uncertain.
Subject:	Pain, postoperative Systematic review Analgesia Surgery, oral Dental implants Network meta-analysis
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE CLÍNICA FAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.4317%2Fmedoral.24639
URI:	http://hdl.handle.net/1843/69318
Issue Date:	19-Aug-2021
metadata.dc.url.externa:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412441/
metadata.dc.relation.ispartof:	Medicina Oral, Patología Oral y Cirugía Bucal
Appears in Collections:	Artigo de Periódico

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