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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/76840
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dc.creatorCaroline Honaiser Lescanopt_BR
dc.creatorIvan Pires de Oliveirapt_BR
dc.creatorFernando Freitas de Limapt_BR
dc.creatorTaline Baganha Stefanello Catelanpt_BR
dc.creatorVictor Hugo Dantas Guimarãespt_BR
dc.creatorUlisses Alves Pereirapt_BR
dc.creatorCharles Martins Aguilarpt_BR
dc.creatorCláudia Andrea Lima Cardosopt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorAlexandre Borgespt_BR
dc.date.accessioned2024-09-24T14:22:27Z-
dc.date.available2024-09-24T14:22:27Z-
dc.date.issued2023-
dc.citation.volume55pt_BR
dc.citation.spage1pt_BR
dc.citation.epage12pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.fbio.2023.102955pt_BR
dc.identifier.issn2212-4292pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/76840-
dc.description.resumoCampomanesia guazumifolia is a species from the Brazilian Cerrado, and its leaves are used by traditional medicine in the preparation of infusion. Its popular uses include antidiarrheal, hypocholesterolemic, and anti-inflammatory purposes. Here we studied the leaf infusion of Campomanesia guazumifolia (LICG) on platelet activity, investigating its role in the cyclooxygenase (COX) pathway. For this, the phytochemical composition, in vivo toxicity (using zebrafish) were evaluated and their effects were investigated on platelet reactivity using different agonists. To elucidate the possible mechanisms involved, we studied the impact of LICG on calcium mobilization, cyclic nucleotides and thromboxane levels, PKCβ2 phosphorylation, and COX inhibition. Furthermore, in silico studies showed the interactions of COX-1 with the compounds identified in LICG by molecular modeling. We describe for the first time that LICG acts by inhibiting platelet aggregation evoked by different physiological agonists, which results in a drastic reduction in intracellular calcium discharge without the involvement of cyclic nucleotide pathways. Furthermore, we showed that LICG appears to inhibit cyclooxygenase 1, reducing thromboxane A2 levels and PKCβ2 phosphorylation in human platelets, reinforced by similar interactions compared to a reference inhibitor at the catalytic site. This study demonstrates the antiplatelet effects of LICG via COX-1 and suggests that these agents may be therapeutic for preventing platelet-associated cardiovascular disease.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFood Bioscience-
dc.rightsAcesso Restritopt_BR
dc.subjectGuabirobapt_BR
dc.subjectPlantas dos cerradospt_BR
dc.subjectFlavonoidespt_BR
dc.subjectCálciopt_BR
dc.subjectTromboxanaspt_BR
dc.subject.otherGuabirobapt_BR
dc.subject.otherPlantas dos cerradospt_BR
dc.subject.otherFlavonoidespt_BR
dc.subject.otherCálciopt_BR
dc.subject.otherTromboxanaspt_BR
dc.titleCampomanesia guazumifolia infusion decreases human platelet aggregation by reducing cyclooxygenase 1 activity and its underlying mechanismspt_BR
dc.title.alternativeA infusão de Campomanesia guazumifolia diminui a agregação plaquetária humana reduzindo a atividade da ciclooxigenase 1 e seus mecanismos subjacentespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2212429223006065pt_BR
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