Estudo da prevalência da doença Celíaca em crianças e adolescentes com diabetes Mellitus tipo 1

Abstract

INTRODUCTION: The association between type 1 diabetes mellitus (T1DM) and celiac disease (CD) has been described since 1954. The prevalence of CD among such patients is 4.1%, considerably higher than the general population (0.5-1%). The aim of this study is to estimate the prevalence of celiac disease in children and adolescents with T1DM treated at the Children's Division of Endocrinology, Hospital das Clínicas, Universidade Federal de Minas Gerais (HC / UFMG). METHODS: Allchildren and adolescents with diagnosis of type 1 diabetes who were followed at Children's Division of Endocrinology, HC/ UFMG, from March 1999 to April 2009, aged 0 to 18 year were included in the study . Total 405 patients, 216 males, mean age 11.26 years. All patients were screened for CD at the first visit and thereafter annually, regardless of clinical symptoms. The investigation was performed through the measurement of IgA (AGAA) and IgG (AGAG) antigliadin antibodies by theELISA technique according Volta et al (1985), modified. Patients with values of AGAA and/or AGAG above two times the cutoff underwent to intestinal biopsy. Patients with AGAA and/or AGAG boderline remained the clinical and laboratory monitoring. RESULTS: Were excluded from the study 15 patients, totaling 390 patients. Of these, 56 (14.3%) had serology AGAA and/or AGAG positive during the annual screening for CD, 31 patients had these values above two times the cutoff and underwent intestinal biopsy for confirmation of CD. The prevalence of CD in children and adolescents with type 1 diabetes followed at the Pediatric Endocrinology Service of HC / UFMG from March 1999 to April 2009 was 3.07%. CONCLUSION: The prevalence of CD in patients with T1DM was higher than that observed in the general population. This study confirms the need for periodic screening of such patients.