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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/39631
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dc.creatorLucilene Rezende Anastáciopt_BR
dc.creatorMarina Chaves de Oliveirapt_BR
dc.creatorKiara Gonçalves Dinizpt_BR
dc.creatorAdaliene Matos Versiane Ferreirapt_BR
dc.creatorAgnaldo Soares Limapt_BR
dc.creatorMaria Isabel Toulson Davisson Correiapt_BR
dc.creatorEduardo Garcia Vilelapt_BR
dc.date.accessioned2022-02-23T23:59:13Z-
dc.date.available2022-02-23T23:59:13Z-
dc.date.issued2016-
dc.citation.volume32pt_BR
dc.citation.issue9pt_BR
dc.citation.spage921pt_BR
dc.citation.epage927pt_BR
dc.identifier.doi10.1016/j.nut.2015.12.038pt_BR
dc.identifier.issn08999007pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/39631-
dc.description.resumoObjective The role of adipokines in liver transplantation (LTx) recipients who have metabolic syndrome (MetS) has seldom been assessed. The aim of this study was to investigate the concentrations of adipokines, inflammatory mediators, and insulin-resistance markers in liver recipients with MetS and its components. Methods Serum samples from 34 patients (55.9% male; 54.9 ± 13.9 y; 7.7 ± 2.9 y after LTx; 50% presented with MetS) were assessed for adiponectin, resistin, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein (MCP)-1, interleukin (IL)-6, C-reactive protein (CRP), homeostatic model assessment-insulin resistance (HOMA-IR) and free fatty acid (FFA) levels. The dosages were uni- and multivariate analyzed to cover MetS (using the Harmonizing MetS criteria), its components, and dietary intake. Results A higher concentration of adiponectin (P < 0.05) was observed among patients with MetS (5.2 ± 3.2 μg/mL) compared with those without MetS (3.2 ± 1.2 μg/mL), as well as those with MetS components versus those without them: abdominal obesity (4.6 ± 2.6 μg/mL versus 2.6 ± 0.6 μg/mL), high triacylglycerols (TGs; 5.6 ± 3.1 μg/mL versus 3 ± 0.9 μg/mL) and low high-density lipoprotein (HDL; 6.1 ± 2.7 μg/mL versus 3.3 ± 1.9 μg/mL). Increased TNF-α and HOMA-IR values were seen in patients with abdominal obesity. Patients with high TGs also had greater FFA values. Independent predictors for adiponectin were waist-to-hip ratio, low HDL and high TGs. High TGs and fasting blood glucose were independent predictors for HOMA-IR. Independent predictors could not be identified for CRP, TNF-α, MCP-1, IL-6, or FFA. Conclusions MetS and its components are related to an increased HOMA-IR concentration and FFA. Adiponectin, resistin, and inflammatory markers, such as TNF-α, IL-6, MCP-1, and CRP, were not associated with MetS in this sample of post-LTx patients.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofNutritionpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectLiver transplantationpt_BR
dc.subjectMetabolic syndromept_BR
dc.subjectObesitypt_BR
dc.subjectAdipokinespt_BR
dc.subjectInsulin resistancept_BR
dc.subject.otherTransplantept_BR
dc.subject.otherFígadopt_BR
dc.titleAdipokines, inflammatory and insulin resistance parameters may not be good markers of metabolic syndrome following liver transplantpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0899900715005353?via%3Dihubpt_BR
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