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http://hdl.handle.net/1843/39648| Type: | Artigo de Periódico |
| Title: | Effect of conjugated linoleic acid-enriched butter after 24 hours of intestinal mucositis induction |
| Authors: | Patrícia Aparecida Vieira de Barros Simone de Vasconcelos Generoso Maria Emília Rabelo Andrade Marco Antonio Sundfeld da Gama Fernando Cesar Ferraz Lopes Éricka Lorenna de Sales Souza e Melo Flaviano dos Santos Martins Sued Eustáquio Mendes Miranda Simone Odília Antunes Fernandes Valbert Nascimento Cardoso |
| Abstract: | Mucositis is the most common side effect due to chemotherapy or radiotherapy. It refers to the inflammation of intestinal mucous membranes, and it is associated with complications such as diarrhea, weight loss, and increased intestinal permeability (IP). This study was designed to evaluate the effect of diet containing conjugated linoleic acid (CLA)-enriched butter on intestinal damage and inflammatory response after 24 h of 5-fluorouracil (5-FU)-induced mucositis. Mice were divided into four groups: CTL; CLA; 5-FU, and CLA 5-FU, and they were fed for 31 days. On the 30th experimental day, mucositis was induced by unique injection of 300 mg/kg of 5-FU. After 24 h (31st experimental day), IP was evaluated; ileum and fecal material were collected to determine cytokine level and myeloperoxidase (MPO) activity and secretory immunoglobulin A (sIgA). The 5-FU group showed an increase in IP and MPO activity (CTL vs. 5-FU: P < 0.05). Additionally, increased levels of IP and MPO were observed in CLA 5-FU group compared to those in the test groups (P < 0.05). Animals in the CLA 5-FU group showed reduced concentrations of sIgA (CTL vs. CLA 5-FU: P < 0.05). CLA-enriched butter exacerbating the 5-FU-induced intestinal damage. Safety concerns regarding the use of CLA require further investigation. |
| Subject: | Dieta Manteiga |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.1080/01635581.2016.1225100 |
| URI: | http://hdl.handle.net/1843/39648 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://www.tandfonline.com/doi/abs/10.1080/01635581.2016.1225100?journalCode=hnuc20 |
| metadata.dc.relation.ispartof: | Nutrition and Cancer |
| Appears in Collections: | Artigo de Periódico |
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