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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/39901
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dc.creatorSara Santos de Carvalhopt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.creatorAdriano de Paula Sabinopt_BR
dc.creatorFernanda Cristina Gontijo Evangelistapt_BR
dc.creatorKarina Braga Gomespt_BR
dc.creatorLuci Maria SantAna Dussept_BR
dc.creatorDanyelle Romana Alves Riospt_BR
dc.date.accessioned2022-03-09T18:45:50Z-
dc.date.available2022-03-09T18:45:50Z-
dc.date.issued2016-03-29-
dc.citation.volume11pt_BR
dc.citation.issue3pt_BR
dc.citation.spage1pt_BR
dc.citation.epage11pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0150613pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/39901-
dc.description.resumoBackground: There is substantial evidence that chronic renal and cardiovascular diseases are associated with coagulation disorders, endothelial dysfunction, inflammation and fibrosis. Angiotensin-Converting Enzyme Insertion/Deletion polymorphism (ACE I/D polymorphism) has also be linked to cardiovascular diseases. Therefore, this study aimed to compare plasma levels of ultrassensible C-reactive protein (usCRP), PAI-1, D-dimer and TGF-β1 in patients undergoing HD with different ACE I/D polymorphisms. Methods: The study was performed in 138 patients at ESRD under hemodialysis therapy for more than six months. The patients were divided into three groups according to the genotype. Genomic DNA was extracted from blood cells (leukocytes). ACE I/D polymorphism was investigated by single polymerase chain reaction (PCR). Plasma levels of D-dimer, PAI-1 and TGF-β1 were measured by enzyme-linked immunosorbent assay (ELISA), and the determination of plasma levels of usCRP was performed by immunonephelometry. Data were analyzed by the software SigmaStat 2.03. Results: Clinical characteristics were similar in patients with these three ACE I/D polymorphisms, except for interdialytic weight gain. I allele could be associated with higher interdialytic weight gain (P =0.017). Patients genotypedas DDandasIDhadsignificantly higher levels of PAI-1 than those with II genotype. Other laboratory parameters did not significantly differ among the three subgroups (P = 0.033). Despite not reaching statistical significance, plasma levels of usCRPwerehigherinpatients carrying the D allele. Conclusion: ACEI/Dpolymorphisms could beassociated with changes in the regulation of sodium, fibrinolytic system, and possibly, inflammation. Our data showed that high levels of PAI-1 are detected when Dallele is present, whereas greater interdialytic gain is associated with the presence of I allele. However, further studies with different experimental designs are necessary to elucidate the mechanisms involved in these associations.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPlos Onept_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherDiálisept_BR
dc.subject.otherPlasmapt_BR
dc.subject.otherDoenças cardiovascularespt_BR
dc.subject.otherInsuficiência renal crônicapt_BR
dc.subject.otherReação em cadeia da polimerasept_BR
dc.subject.otherGenótipopt_BR
dc.subject.otherAlelospt_BR
dc.titleInfluence of ACE I/D polymorphism on circulating levels of plasminogen activator inhibitor 1, D-dimer, ultrasensitive C-reactive protein and transforming growth factor β1 in patients undergoing hemodialysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150613pt_BR
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