1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/40147
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorLuci Maria SantAna Dussept_BR
dc.creatorLara Carvalho Godoipt_BR
dc.creatorKarina Braga Gomes Borgespt_BR
dc.creatorMaria das Graças Carvalhopt_BR
dc.creatorBashir Abdulgader Lwaleedpt_BR
dc.date.accessioned2022-03-16T14:00:02Z-
dc.date.available2022-03-16T14:00:02Z-
dc.date.issued2016-06-
dc.citation.volume27pt_BR
dc.citation.issue4pt_BR
dc.citation.spage436pt_BR
dc.citation.epage440pt_BR
dc.identifier.doi10.1097/MBC.0000000000000507pt_BR
dc.identifier.issn1473-5733pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40147-
dc.description.resumoPreviously we investigated the tissue factor (TF)-dependent coagulation pathway and key haemostatic cofactors in white women with preeclampsia (P-EC) and suggested that plasma factor VII (FVII) levels can differentiate women with P-EC from healthy nonpregnant women or normal pregnant women, at the same trimester, with high sensitivity, specificity, positive and negative predictive values. Here we re-examine the TF-dependent pathway in a large cohort of Brazilian women. A total of 240 women were studied. These included healthy nonpregnant women (n = 79), normotensive pregnant women (n = 80) and women with severe P-EC (n = 81). Commercially available enzyme-linked immunosorbent assays were used to measure plasma FVII, activated factor VII (FVIIa), TF and tissue factor pathway inhibitor (TFPI). All study participants were matched for age. Pregnant women (with/without P-EC) were matched for gestational age and parity. Plasma levels of FVII, FVIIa and TFPI were significantly increased in women with severe P-EC compared with healthy nonpregnant women (P < 0.01) or normotensive pregnant women (P < 0.01). FVIIa was also higher in normotensive pregnant women compared with nonpregnant women (P < 0.01). However, no such significant trends were observed for plasma TF levels (P = 0.074). In conclusion, circulating FVII, FVIIa and TFPI were significantly elevated in women with severe P-EC in the absence of comparable changes in plasma TF levels. The present work is in agreement with our previous report on FVII levels in white women with P-EC. Thus, this lends further support to the notion that plasma FVII levels are potentially valuable diagnostic marker for P-EC, irrespective of ethnicity.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBlood Coagulation and Fibrinolysispt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBloodpt_BR
dc.subjectFactor VIIpt_BR
dc.subjectFactor VIIapt_BR
dc.subjectPlasmapt_BR
dc.subjectPreeclampsiapt_BR
dc.subjectPregnancy complicationspt_BR
dc.subjectTissue factorpt_BR
dc.subjectTissue factor pathway inhibitorpt_BR
dc.subject.otherSanguept_BR
dc.subject.otherFator VIIpt_BR
dc.subject.otherFator VIIapt_BR
dc.subject.otherPlasmapt_BR
dc.subject.otherPré-eclâmpsiapt_BR
dc.subject.otherComplicações na gravidezpt_BR
dc.subject.otherTromboplastinapt_BR
dc.titleTissue factor-dependent pathway in severe preeclampsia revisited: a Brazilian cohort studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.lww.com/bloodcoagulation/Abstract/2016/06000/Tissue_factor_dependent_pathway_in_severe.14.aspxpt_BR
Aparece en las colecciones:Artigo de Periódico

archivos asociados a este elemento:
no existem archivos asociados a este elemento.
Mostrar registro simple del elemento Visualizar estadísticas


Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.