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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40165
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dc.creatorLuiza Oliveira Peruccipt_BR
dc.creatorPatrícia Campi Santospt_BR
dc.creatorLucas Secchim Ribeiropt_BR
dc.creatorDanielle da Glória de Souzapt_BR
dc.creatorKarina Braga Gomes Borgespt_BR
dc.creatorLuci Maria SantAna Dussept_BR
dc.creatorLirlândia Pires de Sousapt_BR
dc.date.accessioned2022-03-16T19:46:18Z-
dc.date.available2022-03-16T19:46:18Z-
dc.date.issued2016-
dc.citation.volume29pt_BR
dc.citation.issue10pt_BR
dc.citation.spage1179pt_BR
dc.citation.epage1185pt_BR
dc.identifier.doihttps://doi.org/10.1093/ajh/hpw053pt_BR
dc.identifier.issn1941-7225pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40165-
dc.description.resumoBackground: Excessive inflammation is involved in preeclampsia (PE) pathogenesis. Lipoxin A4 (LXA4) is an eicosanoid that counter-regulates inflammation. The main objective of this study was to determine LXA4 plasma levels in PE women. The correlations among LXA4 levels, ultrasensitive C-reactive protein (us-CRP) levels, and clinical/laboratory parameters of the studied participants were also investigated. Methods: LXA4 plasma levels were determined by ELISA in 23 nonpregnant, 26 normotensive pregnant, and 27 PE women (early PE (N = 10) and late PE (N = 17)), according to gestational age (GA) at clinical symptoms onset). The clinical/laboratory parameters included in Spearman's correlation analysis were: systolic and diastolic blood pressure (SBP and DBP, respectively), lactate dehydrogenase (LDH) activity, platelet count, proteinuria, and white blood cell count (WBC). Results: LXA4 levels were higher in PE women than in nonpregnant and normotensive pregnant women, and similar between nonpregnant and normotensive pregnant women. LXA4 plasma levels were higher in early PE vs. normotensive pregnancy (GA < 34 weeks) and in late PE vs. normotensive pregnancy (GA ≥ 34 weeks). No significant differences were detected between early and late PE. LXA4 levels were positively correlated with us-CRP levels, SBP, DBP, and WBC. No significant correlation was detected between LXA4 levels and the other laboratory parameters. Conclusions: Chronic inflammation in PE, in spite of increased levels of LXA4, points to a possible failure in this regulatory pathway. Further studies are necessary to clarify this issue and to evaluate the role of LXA4 and other proresolving mediators of inflammation in the pathogenesis of PE.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAmerican Journal of Hypertensionpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBlood pressurept_BR
dc.subjectHypertensionpt_BR
dc.subjectInflammationpt_BR
dc.subjectLipoxin A4pt_BR
dc.subjectPreeclampsiapt_BR
dc.subjectResolutionpt_BR
dc.subject.otherPressão sanguíneapt_BR
dc.subject.otherHipertensãopt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherLipoxinaspt_BR
dc.subject.otherPré-eclâmpsiapt_BR
dc.subject.otherComplicações na gravidezpt_BR
dc.titleLipoxin A4 is increased in the plasma of preeclamptic womenpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://academic.oup.com/ajh/article/29/10/1179/2622235?login=falsept_BR
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