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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/40841
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Campo DCValorIdioma
dc.creatorJuçara Ribeiro Françapt_BR
dc.creatorGiselle Foureauxpt_BR
dc.creatorLeonardo Lima Fuscaldipt_BR
dc.creatorTatiana Gomes Ribeiropt_BR
dc.creatorRachel Oliveira Castilhopt_BR
dc.creatorMaria Irene Yoshidapt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.creatorSebastião Cronembergerpt_BR
dc.creatorJosé Carlos Nogueirapt_BR
dc.creatorAnderson José Ferreirapt_BR
dc.creatorAndré Augusto Gomes Faracopt_BR
dc.date.accessioned2022-04-06T20:42:25Z-
dc.date.available2022-04-06T20:42:25Z-
dc.date.issued2019-10-
dc.citation.volume570pt_BR
dc.citation.spage1pt_BR
dc.citation.epage10pt_BR
dc.identifier.doi10.1016/j.ijpharm.2019.118662pt_BR
dc.identifier.issn0378-5173pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40841-
dc.description.resumoEye drops containing hydrophilic drugs are commonly used to reduce intraocular pressure (IOP) in glaucoma patients, but compliance to the treatement is commonly reduced by frequent dosing and eventual systemic side effects. Sustained-release drug delivery systems, such as ocular inserts, can reduce dosing, limit systemic exposure, reduce side effects, and, then, improve patient adherence to therapy. Here, we developed and evaluated chitosan/hydroxyethyl cellulose-based ocular inserts for sustained release of dorzolamide, a hydrophilic drug. Dorzolamide inserts (DI) were produced by solvent/casting method and characterized by various physicochemical techniques. Pharmacokinetics studies were performed using scintigraphic images and ex vivo biodistribution. The effectiveness of inserts was tested in glaucomatous rats. Characterization studies showed that the drug strongly interacted with the polymeric matrix, but in vitro results showed that DI took only 3 h to release 75% of dorzolamide entraped. However, scintigraphic images and ex vivo biodistribution studies revealed that more than 50% of 99mTc-dorzolamide remained in the eye after 18 h of DI administration, while only about 30% of the drug remained in the eye after drops instilation. DI exerted significant hypotensive effect for two weeks, after single administration, while IOP values remained high in placebo and untreated groups. Eye drops were effective only during the treatment period. Only DI treatment prevented retinal ganglion cells death. Altogether, these findings evidenced the potential application of polymeric-based inserts for sustained release of dorzolamide in glaucoma management.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Pharmaceuticspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSustained-release drug delivery systemspt_BR
dc.subjectOcular insertspt_BR
dc.subjectHydroxyethyl cellulosept_BR
dc.subjectChitosanpt_BR
dc.subjectGlaucomapt_BR
dc.subjectDorzolamidept_BR
dc.subject.otherGlaucomapt_BR
dc.subject.otherQuitosanapt_BR
dc.subject.otherHidroxietilcelulosept_BR
dc.subject.otherDorzolamidapt_BR
dc.titleChitosan/hydroxyethyl cellulose inserts for sustained-release of dorzolamide for glaucoma treatment: in vitro and in vivo evaluationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0378517319307070?via%3Dihubpt_BR
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