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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40864
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dc.creatorMarina Ferrara de Resendept_BR
dc.creatorCleudiomar Inácio Linopt_BR
dc.creatorElaine Maria de Souza-Fagundespt_BR
dc.creatorJoão Vitor Paes Rettorept_BR
dc.creatorRenata Barbosa de Oliveirapt_BR
dc.creatorRenata Adriana Labancapt_BR
dc.date.accessioned2022-04-06T23:35:44Z-
dc.date.available2022-04-06T23:35:44Z-
dc.date.issued2019-06-
dc.citation.volume55pt_BR
dc.citation.spage1pt_BR
dc.citation.epage14pt_BR
dc.identifier.doi10.1590/s2175-97902019000118218pt_BR
dc.identifier.issn2175-9790pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40864-
dc.description.resumoDiabetes mellitus is a chronic disease resulting in oxidative stress that promotes tissue damage. The appearance of this disease is highly related to lifestyle and food of the population, being of great interest to search for a dietary supplement that can also act by reducing oxidative alterations. Based on the broad range of biological activity of thiazole derivatives, this work aimed to evaluate the in vitro antioxidant activity of a novel hydrazine-thiazole derivative and studies in vivo. In in vivo experiments, the liver extracts of healthy and diabetic Wistar rats were used, with analysis to determine the enzymatic activity of SOD, CAT, GPx, and GR, and determination of lipid peroxidation. Finally, in the blood of these animals, biochemical parameters were evaluated. Statistical evidence of changes caused in liver enzymes and liquid peroxidation was not detected; however, these parameters were also not changed between control groups with and without diabetes. On the other hand, concerning biochemical parameters, significant differences were detected in uric acid, alkaline phosphatase, ALT, and urea, indicating a possible antioxidant protective role of such substances in the liver and kidney of diabetic animals that could be acting by means other than that commonly reported in the literature.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectOxidative stresspt_BR
dc.subjectDiabetes mellituspt_BR
dc.subjectCurcuminpt_BR
dc.subjectThiazole derivativespt_BR
dc.subjectDietary supplementpt_BR
dc.subject.otherDiabetes mellituspt_BR
dc.subject.otherCurcuminapt_BR
dc.titleAssessment of anti-diabetic activity of a novel hydrazine-thiazole derivative: in vitro and in vivo methodpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bjps/a/9jk3vMCmNjfjMKrLLBWrfDL/?lang=enpt_BR
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