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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/41756
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Campo DCValorIdioma
dc.creatorVinícius Gonçalves Maltarollopt_BR
dc.creatorMarina Ferrara de Resendept_BR
dc.creatorThales Kronenbergerpt_BR
dc.creatorCleudiomar Inácio Linopt_BR
dc.creatorMaria Clara Pinheiro Duarte Sampaiopt_BR
dc.creatorMaira Galdino da Rocha Pittapt_BR
dc.creatorMoacyr Jesus Barreto de Melo Rêgopt_BR
dc.creatorRenata Adriana Labancapt_BR
dc.creatorRenata Barbosa de Oliveirapt_BR
dc.date.accessioned2022-05-17T15:21:49Z-
dc.date.available2022-05-17T15:21:49Z-
dc.date.issued2019-01-
dc.citation.volume86pt_BR
dc.citation.spage106pt_BR
dc.citation.epage112pt_BR
dc.identifier.doi10.1016/j.jmgm.2018.10.007pt_BR
dc.identifier.issn1093-3263pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41756-
dc.description.resumoThe antioxidant potential of a series of thiazolylhydrazone derivatives was investigated using three different methods namely DPPH, ABTS and FRAP assays. In general, the tested compounds showed higher or comparable activity to that of curcumin, used as positive control. Chemometric analyses demonstrated that the presence of hydrazone moiety is required for the activity of this class of compounds. From these results, compound 4 was identified as the most promising molecule and was then selected for further studies. The antiproliferative effect of compound 4 was evaluated, being active in three (T47D, MDA-MB-231 and SKMEL) of the six cancer cell lines tested, with IC50 values ranging from 15.9 to 31.3 μM. Compound 4 exhibited no detectable cytotoxic effect on peripheral blood mononuclear cells (PBMC) when tested at a concentration of 100 μM, demonstrating good selectivity. From these results, it is possible to infer that there is a correlation between antioxidant capacity and anticancer effects.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Molecular Graphics and Modellingpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAntioxidant activitypt_BR
dc.subject2-Thiazolylhydrazonept_BR
dc.subjectChemometricpt_BR
dc.subjectCytotoxic activitypt_BR
dc.subject.otherTecnologia de alimentospt_BR
dc.subject.otherAtividade antioxidantept_BR
dc.subject.otherEstudos in vitropt_BR
dc.subject.otherEstudos in silicopt_BR
dc.titleIn vitro and in silico studies of antioxidant activity of 2-thiazolylhydrazone derivativespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1093326318304510?via%3Dihubpt_BR
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