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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41833
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dc.creatorIsabella Kuniko Tavares Magalhães Takenakapt_BR
dc.creatorJuliana Mendes Amorimpt_BR
dc.creatorPatrícia Aparecida Vieira de Barrospt_BR
dc.creatorGeraldo Célio Brandãopt_BR
dc.creatorSara Moreira Lopes Contarinipt_BR
dc.creatorÉricka Lorenna de Sales Souza e Melopt_BR
dc.creatorCamila Megale de Almeida-Leitept_BR
dc.creatorFlaviano dos Santos Martinspt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorRachel Oliveira Castilhopt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.date.accessioned2022-05-19T19:23:47Z-
dc.date.available2022-05-19T19:23:47Z-
dc.date.issued2020-
dc.citation.volume30pt_BR
dc.citation.spage559pt_BR
dc.citation.epage567pt_BR
dc.identifier.doi10.1007/s43450-020-00085-7pt_BR
dc.identifier.issn1981-528Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41833-
dc.description.resumoFridericia chica (Bonpl.) L.G. Lohmann, Bignoniaceae, is an Amazonian species known as “pariri” or “crajiru” that is included in the Brazilian National List of Medicinal Plants of Interest to the Unified Health System (Renisus). This herbal remedy is traditionally used as an infusion to treat diarrhea, anemia, inflammation, symptoms of mucositis, and frequent complications of chemotherapy. This study aimed to characterize the chemical profile of the hydroethanolic extract of F. chica and to assess its intestinal anti-inflammatory activity. The chemical profile of the leaves was determined by ultra-performance liquid chromatography coupled to mass spectrometry, and its potential anti-inflammatory activity in the gut was evaluated in mucositis induced by 5-fluorouracil. Three novel compounds from this the species were identified 6,7,3′,4′-tetrahydroxy-5-methoxyflavilium-O-glucuronide, scutellarein-O-glucuronide, and 5-methyl-scutellarein-O-glucuronide, as well as flavones and anthocyanidins that have been previously described. Mice received the hydroethanolic extract (300 mg/kg) for 9 days, and no signs of toxicity were observed. After 72 h of 5-fluorouracil administration, intestinal permeability, bacterial translocation, myeloperoxidase activity, eosinophil peroxidase activity, and histological analyses were performed. Treatment with the analyzed extract was beneficial, as it normalized intestinal permeability, bacterial translocation, myeloperoxidase activity/eosinophil peroxidase and preserved intestinal epithelium architecture. This study provides new insights into the chemical composition and biological activity of the polar extracts from “pariri”, an important Amazonian crude medicinal drug.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista Brasileira de Farmacognosiapt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBacterial translocationpt_BR
dc.subjectChemotherapypt_BR
dc.subjectFlavonoids rich extractpt_BR
dc.subjectIntestinal mucositispt_BR
dc.subjectIntestinal permeabilitypt_BR
dc.subjectPariript_BR
dc.subject.otherPerfil químicopt_BR
dc.subject.otherFridericia chicapt_BR
dc.subject.otherPariript_BR
dc.subject.otherPlantas Medicinaispt_BR
dc.subject.otherCromatografia líquidapt_BR
dc.subject.otherEspectrometria de massaspt_BR
dc.subject.otherCamundongospt_BR
dc.titleChemical characterization and anti-inflammatory assessment of the hydroethanolic extract of Fridericia chicapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s43450-020-00085-7pt_BR
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