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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/42348
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dc.creatorEliane Macedo Sobrinho Santospt_BR
dc.creatorKattyanne de Souza Costapt_BR
dc.creatorAndre Luiz Sena Guimaraespt_BR
dc.creatorLucyana Conceiçao Fariaspt_BR
dc.creatorHercules Otacílio Santospt_BR
dc.creatorJuliana Rezende Sá Miranda Goncalvespt_BR
dc.creatorAnna Christina de Almeidapt_BR
dc.creatorIgor Viana Brandipt_BR
dc.creatorAlex Sander Rodrigues Cangussupt_BR
dc.creatorJanainne Nunes Alvespt_BR
dc.creatorSabrina Ferreira de Jesuspt_BR
dc.creatorRicardo Jardim Neivapt_BR
dc.date.accessioned2022-06-08T12:31:27Z-
dc.date.available2022-06-08T12:31:27Z-
dc.date.issued2018-
dc.citation.volume13pt_BR
dc.citation.issue15pt_BR
dc.citation.spage158pt_BR
dc.citation.epage171pt_BR
dc.identifier.doihttps://doi.org/10.5897/SRE2018.6590pt_BR
dc.identifier.issn1992-2248pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/42348-
dc.description.resumoThis study aimed to investigate, in oral squamous carcinoma cells (OSCC), the antineoplastic effect of Apis mellifera honey produced from Aroeira and wildflower, in the region of Jequitinhonha River Valley, Brazil. Furthermore, we investigate the molecular mechanism of honey performance through bioinformatic analysis. Honey and OSCC-related gene list were screened using GeneCards. The online tool STRING was used to identify the potential interaction networks of protein products of these genes. The genes with the highest weighted number of links (WNL) were called leader genes. GO and KEGG pathway analysis was performed to classify the genes. We use a search tool STITCH for interactions of chemicals-proteins. The chemical characterization of honey and its antiproliferative and antimigratory effects in SCC-9 cell lines was evaluated in vitro. The analysis of the interaction network obtained from the STRING database indicated by the following leader genes: TNF, IL6 and HDAC1. GO analysis for the honey, and OSCC-related proteins revealed that leader genes-regulated cancers genes were markedly enriched in some functions. Through the chemical characterization, the bioactive classes: steroids/triterpenoids, flavonoids, saponins, alkaloids, and tannins were identified. Polyphenols act in activating CASP3 and TP53 and inhibit the action of DNMT1. The honey produced from Aroeira and wildflower reduced proliferative phenotype and migration of OSCC cells.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofScientific research and essayspt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherMel de abelha -- Jequitinhonha, Rio, Vale (MG e BA)pt_BR
dc.subject.otherAroeira do sertãopt_BR
dc.subject.otherAbelha-européiapt_BR
dc.subject.otherMel -- Uso terapêuticopt_BR
dc.titleHoney activity on the proliferation and migration of oral squamous cell carcinoma: in vitro and bioinformatic analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://academicjournals.org/journal/SRE/article-abstract/60EC8D659093ipt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-9836-4117pt_BR
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