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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/43998
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dc.creatorDébora Romualdo Lacerdapt_BR
dc.creatorKátia Anunciação Costapt_BR
dc.creatorAna Letícia Malheiros Silveirapt_BR
dc.creatorDébora Fernandes Rodriguespt_BR
dc.creatorAlbená Nunes Silvapt_BR
dc.creatorJosiana Lopes Sabinopt_BR
dc.creatorVanessa Pinhopt_BR
dc.creatorGustavo Batista de Menezespt_BR
dc.creatorDanusa Dias Soarespt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorAdaliene Versiani Matos Ferreirapt_BR
dc.date.accessioned2022-08-05T12:16:26Z-
dc.date.available2022-08-05T12:16:26Z-
dc.date.issued2019-10-
dc.citation.volume72pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jnutbio.2019.06.006pt_BR
dc.identifier.issn0955-2863pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/43998-
dc.description.resumoInflammation induced by obesity contributes to insulin resistance and atherosclerosis. Indeed, high levels of proinflammatory cytokines trigger chronic low-grade inflammation and promote detrimental metabolic effects in the adipose tissue. On the other hand, inflammation seems to control fat pad expansion and to have important functions on lipolysis and glucose metabolism. Thus, it is possible that inflammation may also drive fat pad loss, as seen during long-fast periods. Herein, we have used fasting as a strategy to induce weight loss and evaluate the possible role of inflammation on adipose tissue remodeling. Male BALB-c mice were fed with chow diet (lean mice) or with high-carbohydrate refined diet (mildly obese mice) for 8 weeks. After that, animals were subjected to 24 h of fasting. There was a 63% reduction of adiposity in lean mice following fasting. Furthermore, the adipose tissue was enriched of immune cells and had a higher content of IL-6, TNF-alpha, IL-10, TGF-β and CXCL-1. Interestingly, mildly obese mice, subjected to the same 24-h fasting period, lost only 33% of their adiposity. Following fasting, these mice did not show any increment in leukocyte recruitment and cytokine levels, as did lean mice. Our findings indicate that inflammation participates in fat mass loss induced by fasting. Although the chronic low-grade inflammation seen in obesity is associated with metabolic diseases, a lower inflammatory response triggered by fasting in mildly obese mice impairs fat pad mobilization.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICApt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Nutritional Biochemistrypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectFastingpt_BR
dc.subjectObesitypt_BR
dc.subjectInflammationpt_BR
dc.subjectCytokinespt_BR
dc.subjectAdipose tissuept_BR
dc.subjectFat losspt_BR
dc.subject.otherJejumpt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherCitocinaspt_BR
dc.subject.otherCitocinaspt_BR
dc.subject.otherTecido adiposopt_BR
dc.subject.otherPerda de pesopt_BR
dc.titleRole of adipose tissue inflammation in fat pad loss induced by fasting in lean and mildly obese micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0955286318304303#:~:text=Our%20findings%20indicate%20that%20inflammation,mice%20impairs%20fat%20pad%20mobilization.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1052-0854pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5236-3124pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1038-2324pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9887-3616pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-5705-8890pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2256-8652pt_BR
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