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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44493
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dc.creatorDeborah de Farias Lelispt_BR
dc.creatorAlexandre Costa Pereirapt_BR
dc.creatorJosé Eduardo Kriegerpt_BR
dc.creatorJosé Geraldo Millpt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorMarcelo Perim Baldopt_BR
dc.date.accessioned2022-08-23T16:45:26Z-
dc.date.available2022-08-23T16:45:26Z-
dc.date.issued2019-
dc.citation.volume63pt_BR
dc.citation.issue4pt_BR
dc.citation.spage402pt_BR
dc.citation.epage410pt_BR
dc.identifier.doihttps://doi.org/10.20945/2359-3997000000155pt_BR
dc.identifier.issn2359-4292pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44493-
dc.description.resumoObjective: the increased prevalence of obesity and associated comorbidities, such as cardiovascular and metabolic diseases, has gained attention worldwide, and the renin-angiotensin system (RAS) has been pointed out as a possible link. Thus, the present study aimed to verify the possible association between angiotensinogen (AGT) or angiotensin-converting enzyme (ACE) polymorphisms with overweight and obesity in adults. Subjects and methods: the present investigation was a population-based cross-sectional study including 1,567 individuals from an urban area in Brazil. Anthropometric, clinical and biochemical parameters were evaluated, and all individuals were genotyped for the ACE I/D and AGT M/T polymorphisms. Results: the prevalence of overweight was higher among men, whereas obesity was more prevalent among women. However, the frequency of ACE or AGT polymorphisms was similar among body mass index (BMI) categories. In addition, the mean age-adjusted BMI averages did not change significantly for ACE or AGT polymorphisms, regardless of sex or BMI category. The age-adjusted BMI average for the combination of ACE and AGT genotypes evidenced no significant differences regardless of sex or BMI categories. Results were similar when BMI was replaced by waist circumference (WC). Conclusions: we were not able to find any associations between BMI and WC (overweight/obesity) and ACE and AGT polymorphisms, indicating that the RAS system might not be involved in overweight and obesity, at least based on genetic backgrounds. However, further studies must measure RAS components to elucidate this question.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArchives of Endocrinology and Metabolismpt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherSistema renina-angiotensinapt_BR
dc.subject.otherPolimorfismo (Genética)pt_BR
dc.subject.otherObesidadept_BR
dc.titlePolymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult populationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/aem/a/DhTYqs78XCTD6nx4bNbYvvx/?lang=enpt_BR
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