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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44579
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dc.creatorCláudio Marcelo Cardosopt_BR
dc.creatorSabrina Ferreira de Jesuspt_BR
dc.creatorMarcela Gonçalves de Souzapt_BR
dc.creatorLorena dos Reis Pereira Queirozpt_BR
dc.creatorEloa Mangabeira Santospt_BR
dc.creatorErivelton Pereira dos Santospt_BR
dc.creatorLuís Paulo Oliveirapt_BR
dc.creatorCristiane Karine Cordeiro Santospt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.date.accessioned2022-08-25T15:45:49Z-
dc.date.available2022-08-25T15:45:49Z-
dc.date.issued2019-07-20-
dc.citation.volume48pt_BR
dc.citation.issue10pt_BR
dc.citation.spage929pt_BR
dc.citation.epage934pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.12932pt_BR
dc.identifier.issn1600-0714pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44579-
dc.description.resumoObjective: malignant salivary gland tumors (MSGTs) present different phenotypic characteristics and various clinical outcomes, which proved to be a diagnostic challenge. Considering the heterogeneity of MSGT, this study aims to identify molecule related to the nature of MSGT. Methods: for screening, proteomic analysis comparing MSGT with pleomorphic adenoma (PA) and salivary gland was performed. The MSGT-associated protein which presented in the higher number in the Gene Expression Omnibus (GEO) database was selected. To validate the data, immunohistochemistry (IHC) was performed in 14 patients with PA, 22 patients with MSGT, and 14 controls. Results: 16 proteins were associated with MSGT. ANXA2 was the primary protein, according to GEO database analyses. ANXA2 was most expressed in the cell membrane. However, some ANXA2 staining was also observed in the cytoplasm and nucleus. ANXA2 was highly expressed in MSGT in comparison with control. Also, ANXA2 has a higher expression in adenocarcinoma not otherwise specified (ANOS) and myoepithelial carcinoma (MC) in comparison with PA. Conclusion: in conclusion, this study demonstrated that MSGT presented higher levels of ANXA2 in comparison with normal salivary glands. Also, ANXA2 might be interesting as a molecular marker of ANOS and MS.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology and Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherBoca - Câncerpt_BR
dc.subject.otherMetástasept_BR
dc.subject.otherTumorespt_BR
dc.subject.otherGlândulas salivares - Doençaspt_BR
dc.titleHigh levels of ANXA2 are characteristic of malignant salivary gland tumorspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12932pt_BR
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