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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/46332
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Campo DCValorIdioma
dc.creatorAna Paula Valentept_BR
dc.creatorAdolfo Henrique de Moraes Silvapt_BR
dc.date.accessioned2022-10-18T19:22:13Z-
dc.date.available2022-10-18T19:22:13Z-
dc.date.issued2019-08-29-
dc.citation.volume25pt_BR
dc.citation.spagee20190013pt_BR
dc.identifier.doihttps://doi.org/10.1590/1678-9199-JVATITD-2019-0013pt_BR
dc.identifier.issn1678-9199pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/46332-
dc.description.resumoIn Brazil and in other tropical areas Zika virus infection was directly associated with clinical complications as microcephaly in newborn children whose mothers were infected during pregnancy and the Guillain-Barré syndrome in adults. Recently, research has been focused on developing new vaccines and drug candidates against Zika virus infection since none of those are available. In order to contribute to vaccine and drug development efforts, it becomes important the understanding of the molecular basis of the Zika virus recognition, infection and blockade. To this purpose, it is essential the structural determination of the Zika virus proteins. The genome sequencing of the Zika virus identified ten proteins, being three structural (protein E, protein C and protein prM) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5). Together, these proteins are the main targets for drugs and antibody recognition. Here we examine new discoveries on high-resolution structural biology of Zika virus, observing the interactions and functions of its proteins identified via state-of-art structural methodologies as X-ray crystallography, nuclear magnetic resonance spectroscopy and cryogenic electronic microscopy. The aim of the present study is to contribute to the understanding of the structural basis of Zika virus infection at an atomic level and to point out similarities and differences to others flaviviruses.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetospt_BR
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiropt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Venomous Animals and Toxins including Tropical Diseasespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectZika virus proteinspt_BR
dc.subjectStructural biologypt_BR
dc.subjectProtein structurept_BR
dc.subjectNuclear magnetic resonance spectroscopypt_BR
dc.subjectProtein-antibody interactionpt_BR
dc.subjectProtein-small compound interactionpt_BR
dc.subject.otherProteínas viraispt_BR
dc.subject.otherProteínaspt_BR
dc.subject.otherBiologiapt_BR
dc.subject.otherEspectroscopia de ressonancia nuclearpt_BR
dc.titleZika virus proteins at an atomic scale: how does structural biology help us to understand and develop vaccines and drugs against zika virus infection?pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/jvatitd/a/WV8JCNrNvVw5SK7BTFrGXXC/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3344-4084pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7219-1123pt_BR
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