1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/46929
Full metadata record
DC FieldValueLanguage
dc.creatorSueli Ferreira da Fonsecapt_BR
dc.creatorVanessa Amaral Mendonçapt_BR
dc.creatorSara Barros Silvapt_BR
dc.creatorTalita Emanuela Dominguespt_BR
dc.creatorDirceu Sousa Melopt_BR
dc.creatorJeanne Brenda Martinspt_BR
dc.creatorWashington Pirespt_BR
dc.creatorCynthia Ferreira Fernandes Santospt_BR
dc.creatorWagner de Fátima Pereirapt_BR
dc.creatorLaura Hora Rios Leitept_BR
dc.creatorCândido Celso Coimbrapt_BR
dc.creatorHércules Ribeiro Leitept_BR
dc.creatorAna Cristina Rodrigues Lacerdapt_BR
dc.date.accessioned2022-11-04T17:36:18Z-
dc.date.available2022-11-04T17:36:18Z-
dc.date.issued2018-10-
dc.citation.volume77pt_BR
dc.citation.spage86pt_BR
dc.citation.epage95pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jtherbio.2018.08.014pt_BR
dc.identifier.issn1879-0992pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/46929-
dc.description.resumoThere is evidence that central cholinergic stimulation increases heat dissipation in normotensive rats besides causing changes on the cardiovascular system via modulation of baroreceptors activity. However, the contribution of the central cholinergic system on thermoregulatory responses and its relationship with cardiovascular adjustments in spontaneously hypertensive rats (SHRs), an animal model of reduced baroreceptor sensitivity and thermoregulatory deficit, has not been completely clarified. Therefore, the aim of this study was to verify the involvement of the central cholinergic system in cardiovascular and thermoregulatory adjustments in SHRs. Male Wistar rats (n = 17) and SHRs (n = 17) were implanted with an intracerebroventricular cannula for injections of 2 µL of physostigmine (phy) or saline solution. Tail temperature (Ttail), internal body temperature (Tint), systolic arterial pressure (SAP), heart rate (HR) and metabolic rate were registered during 60 min while the animals remained at rest after randomly receiving the injections. The variability of the SAP and the HR was estimated by the fast Fourier transform. Phy treatment began a succession of cardiovascular and thermoregulatory responses that resulted in increased SAP, reduced HR and increased Ttail in both Wistar and SHRs groups. The magnitude of these effects seems to be more intense in SHRs, since the improvement of heat dissipation reflected in Tint. Taken together, these results provide evidence that hypertensive rats present greater cardiovascular and thermoregulatory responses than normotensive rats after central cholinergic stimulation.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Thermal Biologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectThermoregulationpt_BR
dc.subjectPhysostigminept_BR
dc.subjectHypertensionpt_BR
dc.subjectCentral cholinergic synapsespt_BR
dc.subject.otherCorpo - Temperatura - Regulaçãopt_BR
dc.subject.otherFisostigminapt_BR
dc.subject.otherHipertensãopt_BR
dc.subject.otherSinapsespt_BR
dc.titleCentral cholinergic activation induces greater thermoregulatory and cardiovascular responses in spontaneously hypertensive than in normotensive ratspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0306456518300986?via%3Dihub#!pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8020-8511pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1696-6091pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7593-7514pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8708-3245pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4982-4388pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8981-6724pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-8977-8131pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5366-3754pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.