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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/46975
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Campo DCValorIdioma
dc.creatorRaquel Duque do Nascimento Arifapt_BR
dc.creatorLuiz Orlando Ladeirapt_BR
dc.creatorKlaus Wilhelm Heinrich Krambrockpt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorDaniele da Glória de Souzapt_BR
dc.creatorTalles Prosperi de Paulapt_BR
dc.creatorMila Fernandes Moreira Madeirapt_BR
dc.creatorRenata Lacerda de Limapt_BR
dc.creatorZélia Menezes Garciapt_BR
dc.creatorThiago Vinicius Ávilapt_BR
dc.creatorVanessa Pinhopt_BR
dc.creatorLuciola da Silva Barcelospt_BR
dc.creatorMauricio Veloso Brant Pinheiropt_BR
dc.date.accessioned2022-11-07T14:50:37Z-
dc.date.available2022-11-07T14:50:37Z-
dc.date.issued2016-
dc.citation.volume107pt_BR
dc.citation.spage102pt_BR
dc.citation.epage110pt_BR
dc.identifier.doihttp://dx.doi.org/10.1016/j.phrs.2016.03.004pt_BR
dc.identifier.issn10436618pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/46975-
dc.description.resumoIrinotecan is a useful chemotherapeutic agent for the treatment of several solid tumors. However, this therapy is associated with side effects, including leukopenia and mucositis. Reactive oxygen species (ROS) activate inflammatory pathways and contribute to Irinotecan-induced mucositis. Fullerol is a nanocomposite with anti-oxidant properties that may reduce tissue damage after inflammatory stimuli. In this paper, the effects of Fullerol and mechanisms of protection were investigated in a model of Irinotecan-induced mucositis. Mucositis was induced by an injection of Irinotecan per 4 days in C57BL/6. Fullerol or a vehicle was injected every 12 h. On day 7, the intestines were removed to evaluate histological changes, leukocyte influx, and the production of cytokines and ROS. Irinotecan therapy resulted in weight loss, an increased clinical score and intestinal injury. Treatment with Fullerol attenuated weight loss, decreased clinical score and intestinal damage. Irinotecan also induced increased ROS production in enterocytes, oxidative stress, IL-1β production, neutrophil and eosinophil influx in the ileum. Fullerol treatment decreased production of ROS in the enterocytes, oxidative stress, IL-1β production, neutrophil and eosinophil influx in the ileum. Irinotecan therapy also induced leukopenia in an ROS-dependent manner because leukopenia reverted in WT mice treated with Fullerol or Apocynin or in Gp91phox-/- mice. Mice treated with Irinotecan presented less melanoma tumor growth compared to the control group. Fullerol does not interfere in the anti-tumor action of Irinotecan. Fullerol has a great pharmacology potential to decreases the severity of mucositis and of leukopenia during chemotherapy treatment.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPharmacological Researchpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectMucositispt_BR
dc.subjectLeukopeniapt_BR
dc.subjectFullerolpt_BR
dc.subjectEnterocytespt_BR
dc.subject.otherFulerolpt_BR
dc.subject.otherTumorespt_BR
dc.titleThe reduction of oxidative stress by nanocomposite fullerol decreases mucositis severity and reverts leukopenia induced by irinotecanpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S104366181630038X?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4935-6070pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7562-0285pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6944-3008pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7478-5934pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3120-5183pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1770-9978pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1600-0289pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1038-2324pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9133-4011pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5722-6260pt_BR
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