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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/47139
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dc.creatorCaroline Amaral Machadopt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.creatorAmanda Silva de Mirandapt_BR
dc.creatorThiago Macedo e Cordeiropt_BR
dc.creatorRodrigo Novaes Ferreirapt_BR
dc.creatorLeonardo Cruz de Souzapt_BR
dc.creatorAntônio Lúcio Teixeirapt_BR
dc.creatorAline Silva de Mirandapt_BR
dc.date.accessioned2022-11-10T19:07:48Z-
dc.date.available2022-11-10T19:07:48Z-
dc.date.issued2020-
dc.citation.volume27pt_BR
dc.citation.issue32pt_BR
dc.citation.spage5374pt_BR
dc.citation.epage5402pt_BR
dc.identifier.doihttp://dx.doi.org/10.2174/0929867326666190710173234pt_BR
dc.identifier.issn1875-533Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/47139-
dc.description.resumoTraumatic Brain Injury (TBI) is a major public health problem. It is the leading cause of death and disability, especially among children and young adults. The neurobiology basis underlying TBI pathophysiology remains to be fully revealed. Over the past years, emerging evidence has supported the hypothesis that TBI is an inflammatory based condition, paving the way for the development of potential therapeutic targets. There is no treatment capable to prevent or minimize TBI associated outcomes. Therefore, the search for effective therapies is a priority goal. In this context, animal models have become valuable tools to study molecular and cellular mechanisms involved in TBI pathogenesis as well as novel treatments. Herein, we discuss therapeutic strategies to treat TBI focused on immunomodulatory and/or anti-inflammatory approaches in the pre-clinical setting.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCurrent Medicinal Chemistrypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectTraumatic brain injurypt_BR
dc.subjectInflammationpt_BR
dc.subjectTreatmentpt_BR
dc.subjectImmunomodulatory agentspt_BR
dc.subjectAnti-inflammatorypt_BR
dc.subjectPathogenesispt_BR
dc.subject.otherCérebropt_BR
dc.subject.otherFerimentos e lesõespt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherAgentes antiinflamatóriospt_BR
dc.titleImmune-based therapies for traumatic brain injury: insights from pre-clinical studiespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.eurekaselect.com/article/99547pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0586-0483pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9222-3882pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8887-2772pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4933-6309pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5987-8622pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5027-9722pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9621-5422pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2811-7924pt_BR
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