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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/47231
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dc.creatorAlice Gameiro Leonelpt_BR
dc.creatorHerman Sander Mansurpt_BR
dc.creatorAlexandra Ancelmo Piscitelli Mansurpt_BR
dc.creatorAnderson Caires de Jesuspt_BR
dc.creatorSandhra Maria de Carvalhopt_BR
dc.creatorKlaus Wilhelm Heinrich Krambrockpt_BR
dc.creatorLuis Eugenio Fernandez Outonpt_BR
dc.creatorJosé Domingos Ardissonpt_BR
dc.date.accessioned2022-11-16T13:16:50Z-
dc.date.available2022-11-16T13:16:50Z-
dc.date.issued2019-
dc.citation.volume132pt_BR
dc.citation.spage677pt_BR
dc.citation.epage691pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ijbiomac.2019.04.006pt_BR
dc.identifier.issn01418130pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/47231-
dc.description.resumoNovel core-shell superparamagnetic nanofluids composed of magnetic iron oxide (Fe3O4, MION) and cobalt-doped (CoxFe3-xO4, Co-MION) nanoparticles functionalized with carboxymethyl cellulose (CMC) ligands were designed and produced via green colloidal aqueous process. The effect of the degree of substitution (DS = 0.7 and 1.2) and molecular mass (Mw) of CMC and cobalt doping concentration on the physicochemical and magnetic properties of these nanoconjugates were comprehensively investigated using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction, transmission electron microscopy (TEM) with selected area electron diffraction, X-ray fluorescence, dynamic light scattering (DLS), zeta potential (ZP) analysis, vibrating sample magnetometry (VSM) and electron paramagnetic resonance spectroscopy (EPR). The results demonstrated the effect of concentration of carboxylate groups and Mw of CMC on the hydrodynamic dimension, zeta potential, and generated heat by magnetic hyperthermia of MION nanoconjugates. Co-doping of MION showed significant alteration of the electrostatic balance of charges of the nanoconjugates interpreted as effect of surface interactions. Moreover, the VSM and EPR results proved the superparamagnetic properties of these nanocolloids, which were affected by the presence of CMC and Co-doping of iron oxide nanoparticles. These magnetic nanohybrids behaved as nanoheaters for killing brain cancer cells in vitro with prospective future applications in oncology and nanomedicine.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetospt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Biological Macromoleculespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPolysaccharidept_BR
dc.subjectCarboxymethyl cellulosept_BR
dc.subjectGreen nanotechnologypt_BR
dc.subjectMagnetic nanoparticlept_BR
dc.subjectNanocompositept_BR
dc.subject.otherPolissacarídeospt_BR
dc.subject.otherNanotecnologiapt_BR
dc.subject.otherNanopartículas magnéticaspt_BR
dc.subject.otherNanocompósitospt_BR
dc.titleSynthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitropt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0141813019305537pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8798-4182pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3032-495Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1526-2508pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2273-2993pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6665-8647pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7562-0285pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3264-337Xpt_BR
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